|SMART accession number:||SM00272|
|Interpro abstract (IPR001928):|
Endothelins (ET's) are the most potent vasoconstrictors known [(PUBMED:2690429), (PUBMED:2168326), (PUBMED:1916094)]. They stimulate cardiac contraction, regulate release of vasoactive substances, and stimulate mitogenesis in blood vessels in primary culture. They also stimulate contraction in almost all other smooth muscles (e.g., uterus, bronchus, vas deferensa and stomach) and stimulate secretion in several tissues (e.g., kidney, liver and adrenals). Endothelin receptors have also been found in the brain, e.g. cerebral cortex, cerebellum and glial cells. Endothelins have been implicated in a variety of pathophysiological conditions associated with stress, including hypertension, myocardial infarction, subarachnoid haemorrhage and renal failure.
Endothelins are synthesised by proteolysis of large preproendothelins, which are cleaved to 'big endothelins' before being processed to the mature peptide.
As shown in the following schematic representation, these peptides which are 21 residues long contain two intramolecular disulphide bonds.
|GO process:||regulation of vasoconstriction (GO:0019229)|
|GO component:||extracellular region (GO:0005576)|
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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