EPEND

Ependymins
EPEND
SMART accession number:SM00026
Description: Ependymins are the predominant proteins in the cerebrospinal fluid (CSF) of teleost fish. They have been implicated in the neurochemistry of memory and neuronal regeneration. They are glycoproteins of about 200 amino acids that can bind calcium. Four cysteines are conserved that probably form disulfide bonds.
Interpro abstract (IPR001299):

Ependymins are secretory proteins found predominantly in the cerebrospinal fluid of teleost fish [(PUBMED:1831964), (PUBMED:8350351)]. A bound form of the glycoproteins is associated with the extracellular matrix, probably with collagen fibrils, that may be the functional form of ependymins [(PUBMED:8005346)]. The proteins bind calcium via N-linked sialic acid residues. The molecular function of ependymins appear to be related to cell contact phenomena involving the extracellular matrix [(PUBMED:8005346)].

GO process:cell-matrix adhesion (GO:0007160)
GO component:extracellular region (GO:0005576)
GO function:calcium ion binding (GO:0005509)
Family alignment:
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There are 47 EPEND domains in 46 proteins in SMART's nrdb database.

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