ERCC4

ERCC4 domain
ERCC4
SMART accession number:SM00891
Description: This entry represents a structural motif found in several DNA repair nucleases, such as Rad1/Mus81/XPF endonucleases, and in ATP-dependent helicases. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases.
Interpro abstract (IPR006166):

This entry represents a structural domain found in several DNA repair nucleases, such as Rad1, XPF and crossover junction endonucleases EME1 and Mus81 [(PUBMED:12679022), (PUBMED:14527419)]. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases.

GO function:DNA binding (GO:0003677), nuclease activity (GO:0004518)
Family alignment:
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There are 1895 ERCC4 domains in 1882 proteins in SMART's nrdb database.

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