FABD

F-actin binding domain (FABD)
FABD
SMART accession number:SM00808
Description: FABD is the F-actin binding domain of Bcr-Abl and its cellular counterpart c-Abl. The Bcr-Abl tyrosine kinase causes different forms of leukemia in humans. Depending on its position within the cell, Bcr-Abl differentially affects cellular growth. The FABD forms a compact left-handed four-helix bundle in solution.
Interpro abstract (IPR015015):

The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function [(PUBMED:16109371)].

GO process:protein phosphorylation (GO:0006468)
GO function:non-membrane spanning protein tyrosine kinase activity (GO:0004715), ATP binding (GO:0005524)
Family alignment:
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There are 85 FABD domains in 85 proteins in SMART's nrdb database.

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