FACT-Spt16_NlobFACT complex subunit SPT16 N-terminal lobe domain
|SMART accession number:||SM01285
||The FACT or facilitator of chromatin transcription complex binds to and alters the properties of nucleosomes. This family represents the N-terminal lobe of the NTD, or N-terminal domain, and acts as a protein-protein interaction domain presumably with partners outside of the FACT complex PMID:18089575. Knockout of the whole NTD domain, 1-450 residues in UniProt:P32558 in yeast serves to tender the cells sensitive to DNA replication stress but is not lethal. The C-terminal half of NTD is structurally similar to aminopeptidases, and the most highly conserved surface residues line a cleft equivalent to the aminopeptidase substrate-binding site, family peptidase_M24, (PFAM:PF00557) PMID:18089575|
There are 0 FACT-Spt16_Nlob domains in 0 proteins in SMART's nrdb database.
Click on the following links for more information.
Cellular role (predicted cellular role)
Links (links to other resources describing this domain)