Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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FANCL_C FANCL C-terminal domain

SMART accession number:	SM01197
Description:	This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 701 FANCL_C domains in 701 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing FANCL_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FANCL_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing FANCL_C domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: interaction
  

• Structure (3D structures containing this domain)

• 3D Structures of FANCL_C domains in PDB

  PDB code	Main view	Title
  3k1l		Crystal Structure of FANCL
  4ccg		Structure of an E2-E3 complex

• Links (links to other resources describing this domain)

• PFAM	FANCL_C

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