A Receptor for Ubiquitination Targets
SMART accession number:SM00256
Interpro abstract (IPR001810):

The F-box domain was first described as a sequence motif found in cyclin-F that interacts with the protein SKP1 [(PUBMED:8706131), (PUBMED:9346238)]. This relatively conserved structural motif is present in numerous proteins and serves as a link between a target protein and a ubiquitin-conjugating enzyme. The SCF complex (e.g., Skp1-Cullin-F-box) plays a similar role as an E3 ligase in the ubiquitin protein degradation pathway [(PUBMED:9499404), (PUBMED:9635407)]. Different F-box proteins as a part of SCF complex recruit particular substrates for ubiquitination through specific protein-protein interaction domains.

Many mammalian F-box domains contain leucine-rich or WD-40 repeats (IPR001680). However, several F-box proteins either have other previously described domains such as Sec7 domain found in FBS protein or do not contain defined protein-protein interaction domains or motifs.

GO function:protein binding (GO:0005515)
Family alignment:
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There are 6748 FBOX domains in 6661 proteins in SMART's nrdb database.

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