FERM_CFERM C-terminal PH-like domain
|SMART accession number:||SM01196|
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- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing FERM_C domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FERM_C domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing FERM_C domain in the selected taxonomic class.
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Frame MC, Patel H, Serrels B, Lietha D, Eck MJ
- The FERM domain: organizing the structure and function of FAK.
- Nat Rev Mol Cell Biol. 2010; 11: 802-14
- Display abstract
Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and cellular partners through its four-point-one, ezrin, radixin,moesin (FERM) domain. Recent structural work reveals that regulatory proteinpartners convert auto-inhibited FAK into its active state by binding to its FERM domain. Further, the identity of FAK FERM domain-interacting proteins yieldsclues as to how FAK coordinates diverse cellular responses, including celladhesion, polarization, migration, survival and death, and suggests that FERMdomains might mediate information transfer between the cell cortex and nucleus.Importantly, the FAK FERM domain might act as a paradigm for the actions of otherFERM domain-containing proteins.
- Structure (3D structures containing this domain)
3D Structures of FERM_C domains in PDB
PDB code Main view Title 1e5w Structure of isolated FERM domain and first long helix of moesin 1ef1 CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX 1gc6 CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE 1gc7 CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN 1gg3 CRYSTAL STRUCTURE OF THE PROTEIN 4.1R MEMBRANE BINDING DOMAIN 1h4r Crystal Structure of the FERM domain of Merlin, the Neurofibromatosis 2 Tumor Suppressor Protein. 1isn Crystal structure of merlin FERM domain 1j19 Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide 1ni2 Structure of the active FERM domain of Ezrin 1sgh Moesin FERM domain bound to EBP50 C-terminal peptide 2d10 Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide 2d11 Crystal structure of the Radixin FERM domain complexed with the NHERF-2 C-terminal tail peptide 2d2q Crystal structure of the dimerized radixin FERM domain 2ems Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule CD43 2emt Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1 2he7 FERM domain of EPB41L3 (DAL-1) 2i1j Moesin from Spodoptera frugiperda at 2.1 angstroms resolution 2i1k Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution 2yvc Crystal structure of the Radixin FERM domain complexed with the NEP cytoplasmic tail 2zpy Crystal structure of the mouse radxin FERM domain complexed with the mouse CD44 cytoplasmic peptide 3bin Structure of the DAL-1 and TSLC1 (372-383) complex 3qij Primitive-monoclinic crystal structure of the FERM domain of protein 4.1R 3u8z human merlin FERM domain 4p7i Crystal structure of the Merlin FERM/DCAF1 complex
- Links (links to other resources describing this domain)