FHA

Forkhead associated domain
FHA
SMART accession number:SM00240
Description: Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.
Interpro abstract (IPR000253):

The forkhead-associated (FHA) domain [(PUBMED:7482699)] is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich, which sometimes contain small helical insertions between the loops connecting the strands [(PUBMED:11911881)].

To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.

GO function:protein binding (GO:0005515)
Family alignment:
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There are 17593 FHA domains in 16684 proteins in SMART's nrdb database.

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