FN2

Fibronectin type 2 domain
FN2
SMART accession number:SM00059
Description: One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.
Interpro abstract (IPR000562): Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis [(PUBMED:3031656)]. The major part of the sequence of fibronectin consists of the repetition of three types of domains, which are called type I, II, and III [(PUBMED:3780752)]. Type II domain is approximately forty residues long, contains four conserved cysteines involved in disulphide bonds and is part of the collagen-binding region of fibronectin. In fibronectin the type II domain is duplicated. Type II domains have also been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma proteins PDC-109 (BSP-A1/A2) and BSP-A3 [(PUBMED:3606570)]; cation-independent mannose-6-phosphate receptor [(PUBMED:1323236)]; mannose receptor of macrophages [(PUBMED:2373685)]; 180 Kd secretory phospholipase A2 receptor [(PUBMED:8294398)]. DEC-205 receptor [(PUBMED:7753172)]; 72 Kd and 92 Kd type IV collagenase (EC 3.4.24.24) [(PUBMED:2834383)]; and hepatocyte growth factor activator [(PUBMED:7683665)].
Family alignment:
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There are 2772 FN2 domains in 1529 proteins in SMART's nrdb database.

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