FTO_NTD

FTO catalytic domain
FTO_NTD
SMART accession number:SM01223
Description: This domain is the catalytic AlkB-like domain from the FTO protein (PUBMED:20376003). This domain catalyses a demethylase activity with a preference for 3-methylthymidine.
Interpro abstract (IPR024367):

This domain is the catalytic AlkB-like domain from the FTO protein [ (PUBMED:20376003) ]. This domain catalyses a demethylase activity with a preference for 3-methylthymidine.

Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation [ (PUBMED:17991826) ]. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. FTO has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine [ (PUBMED:18775698) ]. FTO has no activity towards 1-methylguanine. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. It contributes to the regulation of body size and body fat accumulation as well [ (PUBMED:19234441) ].

Family alignment:
View or

There are 418 FTO_NTD domains in 418 proteins in SMART's nrdb database.

Click on the following links for more information.