Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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FTP eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain

SMART accession number:	SM00607
Description:
Interpro abstract (IPR006585):	Lectins, a group of proteins that bind to cell surface carbohydrates and play important roles in innate immunity, are widely used experimentally to distinguish cell types and to induce cell proliferation. Eel serum lectins have been useful as anti-H hemagglutinins and also in lectin histochemistry as fucose-binding lectins (fucolectins). The fucose-binding lectins are secretory proteins and have unique structures among the lectins, exhibiting only weak similarities to frog pentraxin, horseshoe crab tachylectin-4, and fly fw protein [(PUBMED:10924498)]. This domain of unknown function has been identified in all the Japanese eel (Anguilla japonica) fucolectins and at least one frog pentraxin.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 174 FTP domains in 64 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a FTP domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with FTP domain is also avaliable.

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  Go to specific node: Drosophila melanogaster, Takifugu rubripes

• Structure (3D structures containing this domain)

• 3D Structures of FTP domains in PDB

  PDB code	Main view	Title
  1k12		Fucose binding lectin
  2j1r		Structure of a streptococcus pneumoniae fucose binding module
  2j1s		Structure of a streptococcus pneumoniae fucose binding module in complex with fucose
  2j1t		Structure of a streptococcus pneumoniae fucose binding module in complex with the lewis y antigen
  2j1u		Structure of a streptococcus pneumoniae fucose binding module in complex with the blood group a-tetrasaccharide
  2j1v		Structure of a streptococcus pneumoniae fucose binding module in complex with the blood group h-trisaccharide
  2j22		Structure of a streptococcus pneumoniae fucose binding module, spx-3
  3cqo		Crystal structure of a f-lectin (fucolectin) from morone saxatilis (striped bass) serum

• Links (links to other resources describing this domain)

• INTERPRO	IPR006585

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