The domain within your query sequence starts at position 84 and ends at position 322; the E-value for the Fibrillarin domain shown below is 3.1e-177.
AKVVIEPHRHAGVYIARGKEDLLVTKNMAPGESVYGEKRISVEEPSKEDGVPPTKVEYRV WNPFRSKLAAGIMGGLDELFIAPGKKVLYLGAASGTSVSHVSDVVGPEGVVYAVEFSHRP GRELISMAKKRPNIIPIIEDARHPQKYRMLIGMVDCVFADVAQPDQARIIALNSHMFLKD QGGVVISIKANCIDSTVDAETVFAREVQKLREERIKPLEQLTLEPYERDHCIVVGRYMR
Fibrillarin |
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PFAM accession number: | PF01269 |
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Interpro abstract (IPR000692): | Fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein (SnRNP), functioning in vivo in ribosomal RNA processing [ (PUBMED:2026646) (PUBMED:8493104) ]. It is associated with U3, U8 and U13 small nuclear RNAs in mammals [ (PUBMED:2026646) ] and is similar to the yeast NOP1 protein [ (PUBMED:2686980) ]. Fibrillarin has a well conserved sequence of around 320 amino acids, and contains 3 domains, an N-terminal Gly/Arg-rich region; a central domain resembling other RNA-binding proteins and containing an RNP-2-like consensus sequence; and a C-terminal alpha-helical domain. An evolutionarily related pre-rRNA processing protein, which lacks the Gly/Arg-rich domain, has been found in various archaebacteria. |
GO process: | rRNA processing (GO:0006364) |
GO function: | RNA binding (GO:0003723), methyltransferase activity (GO:0008168) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Fibrillarin