Flavin_Reduct

Flavin reductase like domain
Flavin_Reduct
SMART accession number:SM00903
Description: This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes (PUBMED:12829278), (PUBMED:15461461), (PUBMED:11017201). This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.
Interpro abstract (IPR002563):

The FMN-binding domain is found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes, and various other oxidoreductase and monooxygenase enzymes [(PUBMED:12829278), (PUBMED:15461461), (PUBMED:11017201)].

This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.

GO process:oxidation-reduction process (GO:0055114)
GO function:oxidoreductase activity (GO:0016491), FMN binding (GO:0010181), riboflavin reductase (NADPH) activity (GO:0042602)
Family alignment:
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There are 10652 Flavin_Reduct domains in 10650 proteins in SMART's nrdb database.

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