RNA pol II promoter Fmp27 protein domain
SMART accession number:SM01214
Description: Fmp27_GFWDK is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation (PUBMED:15314641). It contains characteristic GFWDK sequence motifs. Some members are associated with domain Fmp27_SW towards the N terminus.
Interpro abstract (IPR019441):

This domain is found in fungi, metazoans and plants that contains a characteristic GFWDK sequence motif. These include FMP27 and maize protein APT1 and Arabidopsis homologues SABRE and KIP.

The function of the FMP27 protein is not known. FMP27 is the product of a nuclear encoded gene but it is detected in highly purified mitochondria in high-throughput studies [(PUBMED:16823961)]. APT1 is required for pollen tube growth. It is a Golgi-localised protein and appears to regulate vesicular trafficking [(PUBMED:16299389)]. SABRE and KIP are APT1 homologues and they are involved in the elongation of root cortex cells and pollen tubes respectively.

Family alignment:
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There are 1663 Fmp27_GFWDK domains in 1662 proteins in SMART's nrdb database.

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