C-terminal duplication domain of Friend of PRMT1
SMART accession number:SM01218
Description: Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it colocalises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation (PUBMED:19858291).
Interpro abstract (IPR025715):

This LDXXLDAYM region (where X is any amino acid) is duplicated in the C terminus of chromatin target of PRMT1 protein (also known as Fop), which are chromatin-associated proteins that co-localise with facultative heterochromatin and are critical for oestrogen-dependent gene activation [(PUBMED:19858291)]. The region also occurs in other proteins, including THO complex subunit 4 (O08583) and RNA and export factor-binding protein 2 (Q9JJW6).

Family alignment:
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There are 3366 FoP_duplication domains in 3361 proteins in SMART's nrdb database.

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