Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

FoP_duplication C-terminal duplication domain of Friend of PRMT1

SMART accession number:	SM01218
Description:	Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it colocalises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation (PUBMED:19858291).
Interpro abstract (IPR025715):	This LDXXLDAYM region (where X is any amino acid) is duplicated in the C terminus of chromatin target of PRMT1 protein (also known as Fop), which are chromatin-associated proteins that co-localise with facultative heterochromatin and are critical for oestrogen-dependent gene activation [ (PUBMED:19858291) ]. The region also occurs in other proteins, including THO complex subunit 4 ( O08583 ) and RNA and export factor-binding protein 2 ( Q9JJW6 ).
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 3366 FoP_duplication domains in 3361 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing FoP_duplication domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FoP_duplication domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing FoP_duplication domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • van Dijk TB et al.
  • Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.
  • Mol Cell Biol. 2010; 30: 260-72
  • Display abstract

  • We describe the isolation and characterization of Friend of Prmt1 (Fop), a novel chromatin target of protein arginine methyltransferases. Human Fop is encoded by C1orf77, a gene of previously unknown function. We show that Fop is tightlyassociated with chromatin, and that it is modified by both asymmetric andsymmetric arginine methylation in vivo. Furthermore, Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, includingTFF1 (pS2). Fop depletion results in an almost complete block ofestradiol-induced promoter occupancy by the estrogen receptor. Our data indicate that Fop recruitment to the promoter is an early critical event in the activationof estradiol-dependent transcription.

• Links (links to other resources describing this domain)

• INTERPRO	IPR025715
  PFAM	FoP_duplication

Send comments to Ivica Letunic