Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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FtsA Cell division protein FtsA

SMART accession number:	SM00842
Description:	FtsA is essential for bacterial cell division, and co-localizes to the septal ring with FtsZ. It has been suggested that the interaction of FtsA-FtsZ has arisen through coevolution in different bacterial strains (PUBMED:9352931).
Interpro abstract (IPR003494):	FtsA is essential for bacterial cell division, and co-localises to the septal ring with FtsZ. The SHS2 domain, also known as subdomain 1C [ (PUBMED:22473211) ], is inserted into the RNAseH fold of FtsA [ (PUBMED:15281131) ], and is involved in protein-protein interaction [ (PUBMED:9352931) ].
GO process:	cell division (GO:0051301)
GO function:	protein binding (GO:0005515)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 14427 FtsA domains in 14427 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing FtsA domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FtsA domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing FtsA domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: replication
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 33.33 map00473 D-Alanine metabolism 33.33 map03090 Type II secretion system 33.33 map00550 Peptidoglycan biosynthesis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with FtsA domain which could be assigned to a KEGG orthologous group, and not all proteins containing FtsA domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of FtsA domains in PDB

  PDB code	Main view	Title
  3wqt		3WQT
  3wqu		3WQU
  3wt0		3WT0

• Links (links to other resources describing this domain)

• PFAM	FtsA
  INTERPRO	IPR003494

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