GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
SMART accession number:SM00066
Description: Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.
Interpro abstract (IPR001138):

The N-terminal region of a number of fungal transcriptional regulatory proteins contains a Cys-rich motif that is involved in zinc-dependent binding of DNA. The region forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues [ (PUBMED:2107541) (PUBMED:1557122) ]. A wide range of proteins are known to contain this domain. These include the proteins involved in arginine, proline, pyrimidine, quinate, maltose and galactose metabolism; amide and GABA catabolism; leucine biosynthesis, amongst others.

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO function:zinc ion binding (GO:0008270), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)
Family alignment:
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There are 99989 GAL4 domains in 98576 proteins in SMART's nrdb database.

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