GAL4

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
GAL4
SMART accession number:SM00066
Description: Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.
Interpro abstract (IPR001138):

The N-terminal region of a number of fungal transcriptional regulatory proteins contains a Cys-rich motif that is involved in zinc-dependent binding of DNA. The region forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues [(PUBMED:2107541), (PUBMED:1557122)]. A wide range of proteins are known to contain this domain. These include the proteins involved in arginine, proline, pyrimidine, quinate, maltose and galactose metabolism; amide and GABA catabolism; leucine biosynthesis, amongst others.

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO component:nucleus (GO:0005634)
GO function:sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981), zinc ion binding (GO:0008270)
Family alignment:
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There are 23698 GAL4 domains in 23287 proteins in SMART's nrdb database.

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