GGDEF

diguanylate cyclase
GGDEF
SMART accession number:SM00267
Description: Diguanylate cyclase, present in a variety of bacteria.
Interpro abstract (IPR000160):

This domain appears to be ubiquitous in bacteria and is often linked to a regulatory domain, such as a phosphorylation receiver or oxygen sensing domain. Its function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria [(PUBMED:15075296),(PUBMED:15716451)]. Enzymatic activity can be strongly influenced by the adjacent domains. Processes regulated by this domain include exopolysaccharide synthesis, biofilm formation, motility and cell differentiation.

Structural studies of PleD from Caulobacter crescentus show that this domain forms a five-stranded beta sheet surrounded by helices, similar to the catalytic core of adenylate cyclase [(PUBMED:15569936)].

Family alignment:
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There are 17410 GGDEF domains in 17318 proteins in SMART's nrdb database.

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