GIDA_assoc_3

GidA associated domain 3
GIDA_assoc_3
SMART accession number:SM01228
Description: The GidA associated domain 3 is a motif that has been identified at the C-terminus of protein GidA. It consists of 4 helices, the last three being rather short and forming small bundle at the top end of the first longer one. It is here named helical domain 3 because in GidA it is preceded by two other C-terminal helical domain (based on crystal structures PMID:18565343, 19446527). GidA is an tRNA modification enzyme found in bacteria and mitochondrial. Based on mutational analysis this domain has been suggested to be implicated in binding of the D-stem of tRNA (PMID:19446527) and to be responsible for the interaction with protein MnmE PMID:18565343. Structures of GidA in complex with either tRNA or MnmE are missing. Reported to bind to Pfam family MnmE, PF12631.
Family alignment:
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There are 1696 GIDA_assoc_3 domains in 1696 proteins in SMART's nrdb database.

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