GPSG-protein-coupled receptor proteolytic site domain
|SMART accession number:||SM00303|
|Description:||Present in latrophilin/CL-1, sea urchin REJ and polycystin.|
|Interpro abstract (IPR000203):|
This domain has been termed the GPS domain (for GPCR proteolytic site), because it contains a cleavage site in O97830 latrophilin [(PUBMED:9920906)]. However this region in latrophilin is found in many otherwise unrelated cell surface receptors [(PUBMED:10469603)]. There is no evidence currently that this domain provides a cleavage site in any of the other receptors. However the peptide bond that is cleaved in latrophilin is between Leu and Thr residues that are conserved in some of the other receptors [(PUBMED:10469603)].
GPS domains are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.
|GO process:||neuropeptide signaling pathway (GO:0007218)|
|GO component:||membrane (GO:0016020)|
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- Evolution (species in which this domain is found)
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