G-protein-coupled receptor proteolytic site domain
SMART accession number:SM00303
Description: Present in latrophilin/CL-1, sea urchin REJ and polycystin.
Interpro abstract (IPR000203):

This domain has been termed the GPS domain (for GPCR proteolytic site), because it contains a cleavage site in O97830 latrophilin [(PUBMED:9920906)]. However this region in latrophilin is found in many otherwise unrelated cell surface receptors [(PUBMED:10469603)]. There is no evidence currently that this domain provides a cleavage site in any of the other receptors. However the peptide bond that is cleaved in latrophilin is between Leu and Thr residues that are conserved in some of the other receptors [(PUBMED:10469603)].

GPS domains are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.

| |
+-----------------+---------------+ |
| | | |
cleavage site
GO process:neuropeptide signaling pathway (GO:0007218)
GO component:membrane (GO:0016020)
Family alignment:
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There are 1492 GPS domains in 1485 proteins in SMART's nrdb database.

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