GPSG-protein-coupled receptor proteolytic site domain
|SMART accession number:||SM00303|
|Description:||Present in latrophilin/CL-1, sea urchin REJ and polycystin.|
|Interpro abstract (IPR000203):|
This motif has been termed GPS (for GPCR proteolytic site), because it contains a cleavage site in O97830 latrophilin [(PUBMED:9920906)]. This motif is also found in many otherwise unrelated cell surface receptors [(PUBMED:10469603)].
GPS motifs are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.
The GPS motif is an integral part of a much larger (320-residue approximately) domain that has been termed GPCR-Autoproteolysis INducing (GAIN) domain. The GAIN domain represents an autoproteolytic fold whose function is likely relevant for GPCR signalling [(PUBMED:22333914)].
|GO process:||neuropeptide signaling pathway (GO:0007218)|
|GO component:||membrane (GO:0016020)|
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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