SMART: Gal-bind_lectin domain annotation

Gal-bind_lectin Galactoside-binding lectin

SMART accession number:	SM00908
Description:	Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals (PUBMED:8124704). Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.
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There are 1095 Gal-bind_lectin domains in 791 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Click on to expand nodes. To display all proteins with a Gal-bind_lectin domain in a specific node, click on it.

This tree shows only several representative species. The complete taxonomic breakdown of all proteins with Gal-bind_lectin domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: metabolism
Structure (3D structures containing this domain)

3D Structures of Gal-bind_lectin domains in PDB

PDB code	Main view	Title
1a3k		X-ray crystal structure of the human galectin-3 carbohydrate recognition domain (crd) at 2.1 angstrom resolution
1a78		Complex of toad ovary galectin with thio-digalactose
1bkz		Crystal structure of human galectin-7
1c1f		Ligand-free congerin i
1c1l		Lactose-liganded congerin i
1g86		Charcot-leyden crystal protein/n-ethylmaleimide complex
1gan		Complex of toad ovary galectin with n-acetylgalactose
1gzw		X-ray crystal structure of human galectin-1
1hdk		Charcot-leyden crystal protein - pcmbs complex
1hlc		X-ray crystal structure of the human dimeric s-lac lectin, l-14-ii, in complex with lactose at 2.9 angstroms resolution
1is3		Lactose and mes-liganded congerin ii
1is4		Lactose-liganded congerin ii
1is5		Ligand free congerin ii
1is6		Mes-liganded congerin ii
1kjl		High resolution x-ray structure of human galectin-3 in complex with lacnac
1kjr		Crystal structure of the human galectin-3 crd in complex with a 3'-derivative of n-acetyllactosamine
1lcl		Charcot-leyden crystal protein
1qkq		Charcot-leyden crystal protein - mannose complex
1qmj		Cg-16, a homodimeric agglutinin from chicken liver
1sla		X-ray crystallography reveals crosslinking of mammalian lectin (galectin-1) by biantennary complex type saccharides
1slb		X-ray crystallography reveals crosslinking of mammalian lectin (galectin-1) by biantennary complex type saccharides
1slc		X-ray crystallography reveals crosslinking of mammalian lectin (galectin-1) by biantennary complex type saccharides
1slt		Structure of s-lectin, a developmentally regulated vertebrate beta-galactoside binding protein
1ul9		Cgl2 ligandfree
1ulc		Cgl2 in complex with lactose
1uld		Cgl2 in complex with blood group h type ii
1ule		Cgl2 in complex with linear b2 trisaccharide
1ulf		Cgl2 in complex with blood group a tetrasaccharide
1ulg		Cgl2 in complex with thomsen-friedenreich antigen
1w6m		X-ray crystal structure of c2s human galectin-1 complexed with galactose
1w6n		X-ray crystal structure of c2s human galectin-1
1w6o		X-ray crystal structure of c2s human galectin-1 complexed with lactose
1w6p		X-ray crystal structure of c2s human galectin-1 complexed with n-acetyl-lactosamine
1w6q		X-ray crystal structure of r111h human galectin-1
1wlc		Congerin ii y16s/t88i double mutant
1wld		Congerin ii t88i single mutant
1wlw		Congerin ii y16s single mutant
1x50		Solution structure of the c-terminal gal-bind lectin domain from human galectin-4
2d6k		Crystal structure of mouse galectin-9 n-terminal crd (crystal form 1)
2d6l		Crystal structure of mouse galectin-9 n-terminal crd (crystal form 2)
2d6m		Crystal structure of mouse galectin-9 n-terminal crd in complex with lactose
2d6n		Crystal structure of mouse galectin-9 n-terminal crd in complex with n-acetyllactosamine
2d6o		Crystal structure of mouse galectin-9 n-terminal crd in complex with n-acetyllactosamine dimer
2d6p		Crystal structure of mouse galectin-9 n-terminal crd in complex with t-antigen
2dyc		Crystal structure of the n-terminal domain of mouse galectin-4
2eak		Crystal structure of human galectin-9 n-terminal crd in complex with lactose
2eal		Crystal structure of human galectin-9 n-terminal crd in complex with forssman pentasaccharide
2gal		Crystal structure of human galectin-7 in complex with galactose
2jj6		Crystal structure of the putative carbohydrate recognition domain of the human galectin-related protein
2nmn		Crystal structure of human galectin-3 carbohydrate- recognising domain at 2.45 angstrom resolution
2nmo		Crystal structure of human galectin-3 carbohydrate- recognition domain at 1.35 angstrom resolution
2nn8		Crystal structure of human galectin-3 carbohydrate- recognition domain with lactose bound, at 1.35 angstrom resolution
2yro		Solution structure of the c-terminal gal-bind lectin protein from human galectin-8
2yv8		Crystal structure of n-terminal domain of human galectin-8
2yxs		Crystal sturcture of n-terminal domain of human galectin-8 with d-lactose
2yy1		Crystal sturcture of n-terminal domain of human galectin-9 containing l-acetyllactosamine
2zhk		Crystal structure of human galectin-9 n-terminal crd in complex with n-acetyllactosamine dimer (crystal 1)
2zhl		Crystal structure of human galectin-9 n-terminal crd in complex with n-acetyllactosamine dimer (crystal 2)
2zhm		Crystal structure of human galectin-9 n-terminal crd in complex with n-acetyllactosamine trimer (crystal 1)
2zhn		Crystal structure of human galectin-9 n-terminal crd in complex with n-acetyllactosamine trimer (crystal 2)
2zkn		X-ray structure of mutant galectin-1/lactose complex
3b9c		Crystal structure of human grp crd
3dui		Crystal structure of the oxidized cg-1b: an adhesion/growth- regulatory lectin from chicken
3gal		Crystal structure of human galectin-7 in complex with galactosamine
4gal		Crystal structure of human galectin-7 in complex with lactose
5gal		Crystal structure of human galectin-7 in complex with n- acetyllactosamine

Links (links to other resources describing this domain)
PFAM Gal-bind_lectin