H4

Histone H4
H4
SMART accession number:SM00417
Description: -
Interpro abstract (IPR001951): Histone H4 is one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling [(PUBMED:15606770)]. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [(PUBMED:8121801), (PUBMED:6808351), (PUBMED:3340182)].
GO process:nucleosome assembly (GO:0006334)
GO component:nucleus (GO:0005634), nucleosome (GO:0000786)
GO function:DNA binding (GO:0003677)
Family alignment:
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There are 2386 H4 domains in 839 proteins in SMART's nrdb database.

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