SMART: HATPase_c domain annotation

HATPase_c Histidine kinase-like ATPases

SMART accession number:	SM00387
Description:	Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Interpro abstract (IPR003594):	This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [(PUBMED:15105144)], heat shock protein HSP90 [(PUBMED:15292259), (PUBMED:14718169), (PUBMED:15217611)], phytochrome-like ATPases and DNA mismatch repair proteins. The fold of this domain consists of two layers, alpha/beta, which contains an 8-stranded mixed beta-sheet. More information about this protein can be found at Protein of the Month: DNA Topoisomerase [].
GO function:	ATP binding (GO:0005524)
Family alignment:	View or

There are 65688 HATPase_c domains in 65522 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Click on to expand nodes. To display all proteins with a HATPase_c domain in a specific node, click on it.

This tree shows only several representative species. The complete taxonomic breakdown of all proteins with HATPase_c domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: signalling
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of HATPase_c domains in PDB

PDB code	Main view	Title
1a4h		Structure of the n-terminal domain of the yeast hsp90 chaperone in complex with geldanamycin
1ah6		Structure of the tetragonal form of the n-terminal domain of the yeast hsp90 chaperone
1ah8		Structure of the orthorhombic form of the n-terminal domain of the yeast hsp90 chaperone
1aj6		Novobiocin-resistant mutant (r136h) of the n-terminal 24 kda fragment of dna gyrase b complexed with novobiocin at 2.3 angstroms resolution
1am1		Atp binding site in the hsp90 molecular chaperone
1amw		Adp binding site in the hsp90 molecular chaperone
1b3q		Crystal structure of chea-289, a signal transducing histidine kinase
1b62		Mutl complexed with adp
1b63		Mutl complexed with adpnp
1bgq		Radicicol bound to the atp binding site of the n-terminal domain of the yeast hsp90 chaperone
1bkn		Crystal structure of an n-terminal 40kd fragment of e. coli dna mismatch repair protein mutl
1bxd		Nmr structure of the histidine kinase domain of the e. coli osmosensor envz
1byq		Hsp90 n-terminal domain bound to adp-mg
1ea6		N-terminal 40kda fragment of nhpms2 complexed with adp
1ei1		Dimerization of e. coli dna gyrase b provides a structural mechanism for activating the atpase catalytic center
1gjv		Branched-chain alpha-ketoacid dehydrogenase kinase (bck) complxed with atp-gamma-s
1gkx		Branched-chain alpha-ketoacid dehydrogenase kinase (bck)
1gkz		Branched-chain alpha-ketoacid dehydrogenase kinase (bck) complxed with adp
1h7s		N-terminal 40kda fragment of human pms2
1h7u		Hpms2-atpgs
1i58		Structure of the histidine kinase chea atp-binding domain in complex with atp analog adpcp and magnesium
1i59		Structure of the histidine kinase chea atp-binding domain in complex with adpnp and magensium
1i5a		Structure of chea domain p4 in complex with adpcp and manganese
1i5b		Structure of chea domain p4 in complex with adpnp and manganese
1i5c		Structure of chea domain p4 in complex with adp
1i5d		Structure of chea domain p4 in complex with tnp-atp
1id0		Crystal structure of the nucleotide bond conformation of phoq kinase domain
1jm6		Pyruvate dehydrogenase kinase, isozyme 2, containing adp
1kij		Crystal structure of the 43k atpase domain of thermus thermophilus gyrase b in complex with novobiocin
1kzn		Crystal structure of e. coli 24kda domain in complex with clorobiocin
1l0o		Crystal structure of the bacillus stearothermophilus anti- sigma factor spoiiab with the sporulation sigma factor sigmaf
1mu5		Structure of topoisomerase subunit
1mx0		Structure of topoisomerase subunit
1nhh		Crystal structure of n-terminal 40kd mutl protein (ln40) complex with adpnp and one rubidium
1nhi		Crystal structure of n-terminal 40kd mutl (ln40) complex with adpnp and one potassium
1nhj		Crystal structure of n-terminal 40kd mutl/a100p mutant protein complex with adpnp and one sodium
1osf		Human hsp90 in complex with 17-desmethoxy-17-n,n- dimethylaminoethylamino-geldanamycin
1pvg		Crystal structure of the atpase region of saccharomyces cerevisiae topoisomerase ii
1qy5		Crystal structure of the n-domain of the er hsp90 chaperone grp94 in complex with the specific ligand neca
1qy8		Crystal structure of the n-domain of the er hsp90 chaperone grp94 in complex with radicicol
1qye		Crystal structure of the n-domain of the er hsp90 chaperone grp94 in complex with 2-chlorodideoxyadenosine
1qzr		Crystal structure of the atpase region of saccharomyces cerevisiae topoisomerase ii bound to icrf-187 (dexrazoxane)
1r62		Crystal structure of the c-terminal domain of the two- component system transmitter protein nrii (ntrb)
1s14		Crystal structure of escherichia coli topoisomerase iv pare 24kda subunit
1s16		Crystal structure of e. coli topoisomerase iv pare 43kda subunit complexed with adpnp
1tbw		Ligand induced conformational shift in the n-terminal domain of grp94, open conformation
1tc0		Ligand induced conformational shifts in the n-terminal domain of grp94, open conformation complexed with the physiological partner atp
1tc6		Ligand induced conformational shift in the n-terminal domain of grp94, open conformation adp-complex
1th8		Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa: inhibitory complex with adp, crystal form ii
1thn		Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa: inhibitory complex with adp, crystal form i
1tid		Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa: poised for phosphorylation complex with atp, crystal form i
1til		Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa:poised for phosphorylation complex with atp, crystal form ii
1u0y		N-domain of grp94, with the charged domain, in complex with the novel ligand n-propyl carboxyamido adenosine
1u0z		N-domain of grp94 lacking the charged domain in complex with radicicol
1u2o		Crystal structure of the n-domain of grp94 lacking the charged domain in complex with neca
1us7		Complex of hsp90 and p50
1uy6		Human hsp90-alpha with 9-butyl-8-(3,4,5-trimethoxy-benzyl)-9h-purin-6-ylamine
1uy7		Human hsp90-alpha with 9-butyl-8-(4-methoxy-benzyl)-9h-purin-6-ylamine
1uy8		Human hsp90-alpha with 9-butyl-8-(3-trimethoxy-benzyl)-9h-purin-6ylamine
1uy9		Human hsp90-alpha with 8-benzo[1,3]dioxol-,5-ylmethyl-9-butyl-9h-purin-6-ylamine
1uyc		Human hsp90-alpha with 9-butyl-8-(2,5-dimethoxy-benzyl)-9h-purin-6-ylamine
1uyd		Human hsp90-alpha with 9-butyl-8- (2-chloro-3,4,5-trimethoxy-benzyl)-9h-purin-6-ylamine
1uye		Human hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl) -9-pent-4-ylnyl-9h-purin-6-ylamine
1uyf		Human hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl) -2-fluoro-9-pent-4-ylnyl-9h-purin-6-ylamine
1uyg		Human hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9h-purin-6-ylamine
1uyh		Human hsp90-alpha with 9-butyl-8- (2,5-dimethoxy-benzyl)-2-fluoro-9h-purin-6-ylamine
1uyi		Human hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9- pent-9h-purin-6-ylamine
1uyk		Human hsp90-alpha with 8-benzo[1,3]dioxol-,5-ylmethyl-9-but yl-2-fluoro-9h-purin-6-ylamine
1uyl		Structure-activity relationships in purine-based inhibitor binding to hsp90 isoforms
1uym		Human hsp90-beta with pu3 (9-butyl-8(3,4,5-trimethoxy-benzyl)-9h-purin-6-ylamine)
1y4s		Conformation rearrangement of heat shock protein 90 upon adp binding
1y4u		Conformation rearrangement of heat shock protein 90 upon adp binding
1y8n		Crystal structure of the pdk3-l2 complex
1y8o		Crystal structure of the pdk3-l2 complex
1y8p		Crystal structure of the pdk3-l2 complex
1yc1		Crystal structures of human hsp90alpha complexed with dihydroxyphenylpyrazoles
1yc3		Crystal structure of human hsp90alpha complexed with dihydroxyphenylpyrazoles
1yc4		Crystal structure of human hsp90alpha complexed with dihydroxyphenylpyrazoles
1yer		Human hsp90 geldanamycin-binding domain, "closed" conformation
1yes		Human hsp90 geldanamycin-binding domain, "open" conformation
1yet		Geldanamycin bound to the hsp90 geldanamycin-binding domain
1ys3		Crystal structure of the atp binding domain of prrb from mycobacterium tuberculosis
1ysr		Crystal structure of atp binding domain of prrb from mycobacterium tuberculosis
1ysz		Crystal structure of the unliganded form of grp94, the er hsp90: basis for nucleotide-induced conformational change, grp94n(delta)41 apo crystal soaked with neca
1yt0		Crystal structure of the unliganded form of grp94, the er hsp90: basis for nucleotide-induced conformational change, grp94n(delta)41 apo crystal soaked with adp
1yt1		Crystal structure of the unliganded form of grp94, the er hsp90: basis for nucleotide-induced conformational change, grp94n(delta)41 apo crystal
1yt2		Crystal structure of the unliganded form of grp94, the er hsp90: basis for nucleotide-induced conformational change, grp94n apo crystal
1z59		Topoisomerase vi-b, adp-bound monomer form
1z5a		Topoisomerase vi-b, adp-bound dimer form
1z5b		Topoisomerase vi-b, adp alf4- bound dimer form
1z5c		Topoisomerase vi-b, adp pi bound dimer form
1zw9		Yeast hsp82 in complex with the novel hsp90 inhibitor 8-(6- bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino- propyl)-adenine
1zwh		Yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
1zxm		Human topo iia atpase/amp-pnp
1zxn		Human dna topoisomerase iia atpase/adp
2akp		Hsp90 delta24-n210 mutant
2brc		Structure of a hsp90 inhibitor bound to the n-terminus of yeast hsp90.
2bre		Structure of a hsp90 inhibitor bound to the n-terminus of yeast hsp90.
2bsm		Novel, potent small molecule inhibitors of the molecular chaperone hsp90 discovered through structure-based design
2bt0		Novel, potent small molecule inhibitors of the molecular chaperone hsp90 discovered through structure-based design
2btz		Crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu2		Crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu5		Crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu6		Crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu7		Crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2bu8		Crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
2byh		3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the hsp90 molecular chaperone
2byi		3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the hsp90 molecular chaperone
2bz5		Structure-based discovery of a new class of hsp90 inhibitors
2c2a		Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
2ccs		Human hsp90 with 4-chloro-6-(4-piperazin-1-yl-1h-pyrazol-3- yl)-benzene-1,2-diol
2cct		Human hsp90 with 5-(5-chloro-2,4-dihydroxy-phenyl)-4- piperazin-1-yl-2h-pyrazole-3-carboxylic acid ethylamide
2ccu		Human hsp90 with 4-chloro-6-(4-(4-(4-methanesulphonyl- benzyl)-pierazin-1-yl)-1h-pyrazol-3-yl)-benzene-1,3-diol
2cdd		Human hsp90 with 4-(4-(2,3-dihydro-benzol(1,4)dioxin-6-yl)- 5-methyl-1h-pyrazol-3-yl)-6-ethyl-benzene-1,3-diol
2cg9		Crystal structure of an hsp90-sba1 closed chaperone complex
2cgf		A radicicol analogue bound to the atp binding site of the n- terminal domain of the yeast hsp90 chaperone
2ch4		Complex between bacterial chemotaxis histidine kinase chea domains p4 and p5 and receptor-adaptor protein chew
2e0a		Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with amppnp
2esa		Grp94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 ks-aa
2exl		Grp94 n-terminal domain bound to geldanamycin
2fwy		Structure of human hsp90-alpha bound to the potent water soluble inhibitor pu-h64
2fwz		Structure of human hsp90-alpha bound to the potent water soluble inhibitor pu-h71
2fxs		Yeast hsp82 in complex with the novel hsp90 inhibitor radamide
2fyp		Grp94 in complex with the novel hsp90 inhibitor radester amine
2gfd		Grp94 in complex with the novel hsp90 inhibitor radamide
2gqp		N-domain of grp94 in complex with the novel ligand n-propyl carboxyamido adenosine
2h55		Structure of human hsp90-alpha bound to the potent water soluble inhibitor pu-dz8
2h8m		N-domain of grp94 in complex with the 2-iodo-neca
2hch		N-domain of grp94 in complex with the novel ligand n-(2- amino)ethyl carboxyamido adenosine
2hg1		N-domain of grp94 in complex with the novel ligand n-(2- hydroxyl)ethyl carboxyamido adenosine
2hkj		Topoisomerase vi-b bound to radicicol
2iop		Crystal structure of full-length htpg, the escherichia coli hsp90, bound to adp
2ioq		Crystal structure of full-length htpg, the escherichia coli hsp90
2ior		Crystal structure of the n-terminal domain of htpg, the escherichia coli hsp90, bound to adp
2iws		Radicicol analogues bound to the atp site of hsp90
2iwu		Analogues of radicicol bound to the atp-binding site of hsp90
2iwx		Analogues of radicicol bound to the atp-binding site of hsp90.
2jjc		Hsp90 alpha atpase domain with bound small molecule fragment
2jki		Complex of hsp90 n-terminal and sgt1 cs domain
2k5b		Human cdc37-hsp90 docking model based on nmr
2o1u		Structure of full length grp94 with amp-pnp bound
2o1v		Structure of full length grp94 with adp bound
2o1w		Structure of n-terminal plus middle domains (n+m) of grp94
2pnr		Crystal structure of the asymmetric pdk3-l2 complex
2q2e		Crystal structure of the topoisomerase vi holoenzyme from methanosarcina mazei
2q8f		Structure of pyruvate dehydrogenase kinase isoform 1
2q8g		Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug azd7545
2q8h		Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca)
2q8i		Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol
2qf6		Hsp90 complexed with a56322
2qfo		Hsp90 complexed with a143571 and a516383
2qg0		Hsp90 complexed with a943037
2qg2		Hsp90 complexed with a917985
2uwd		Inhibition of the hsp90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs
2vci		4,5 diaryl isoxazole hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer
2vcj		4,5 diaryl isoxazole hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer
2vw5		Structure of the hsp90 inhibitor 7-o-carbamoylpremacbecin bound to the n- terminus of yeast hsp90
2vwc		Structure of the hsp90 inhibitor macbecin bound to the n- terminus of yeast hsp90.
2wep		Yeast hsp90 n-terminal domain li-iv mutant with adp
2weq		Yeast hsp90 n-terminal domain li-iv mutant with geldanamycin
2wer		Yeast hsp90 n-terminal domain li-iv mutant with radicicol
2wi1		Orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
2wi2		Orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
2wi3		Orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
2wi4		Orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
2wi5		Orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
2wi6		Orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
2wi7		Orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
2zbk		Crystal structure of an intact type ii dna topoisomerase: insights into dna transfer mechanisms
2zdx		Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
2zdy		Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
2zkj		Crystal structure of human pdk4-adp complex
3a0r		Crystal structure of histidine kinase thka (tm1359) in complex with response regulator protein trra (tm1360)
3a0t		Catalytic domain of histidine kinase thka (tm1359) in complex with adp and mg ion (trigonal)
3a0w		Catalytic domain of histidine kinase thka (tm1359) for mad phasing (nucleotide free form 2, orthorombic)
3a0x		Catalytic domain of histidine kinase thka (tm1359) (nucleotide free form 1: ammomium phosphate, monoclinic)
3a0y		Catalytic domain of histidine kinase thka (tm1359) (nucleotide free form 3: 1,2-propanediol, orthorombic)
3a0z		Catalytic domain of histidine kinase thka (tm1359) (nucleotide free form 4: isopropanol, orthorombic)
3bm9		Discovery of benzisoxazoles as potent inhibitors of chaperone hsp90
3bmy		Discovery of benzisoxazoles as potent inhibitors of chaperone hsp90
3c0e		Yeast hsp82 n-terminal domain: effects of mutants 98-99 ks- aa
3c11		Yeast hsp82 n-terminal domain-geldanamycin complex: effects of mutants 98-99 ks-aa
3cgy		Crystal structure of salmonella sensor kinase phoq catalytic domain in complex with radicicol
3cgz		Crystal structure of salmonella sensor kinase phoq catalytic domain
3crk		Crystal structure of the pdhk2-l2 complex.
3crl		Crystal structure of the pdhk2-l2 complex.
3d0b		Crystal structure of benzamide tetrahydro-4h-carbazol-4-one bound to hsp90
3d2r		Crystal structure of pyruvate dehydrogenase kinase isoform in complex with adp
3d36		How to switch off a histidine kinase: crystal structure of geobacillus stearothermophilus kinb with the inhibitor sda
3dge		Structure of a histidine kinase-response regulator complex reveals insights into two-component signaling and a novel cis-autophosphorylation mechanism
3ehf		Crystal structure of deskc in complex with amp-pcp
3ehg		Crystal structure of the atp-binding domain of desk in complex with atp
3ehh		Crystal structure of deskc-h188v in complex with adp
3ehj		Crystal structure of deskc-h188v in complex with amp-pcp
3eko		Dihydroxylphenyl amides as inhibitors of the hsp90 molecular chaperone
3ekr		Dihydroxylphenyl amides as inhibitors of the hsp90 molecular chaperone
3ft5		Structure of hsp90 bound with a novel fragment
3ft8		Structure of hsp90 bound with a noval fragment.
3gie		Crystal structure of deskc_h188e in complex with amp-pcp
3gif		Crystal structure of deskc_h188e in complex with adp
3gig		Crystal structure of phosphorylated deskc in complex with amp-pcp
3h80		Crystal structure of the amino-terminal domain of hsp90 from leishmania major, lmjf33.0312:m1-k213
3hek		Hsp90 n-terminal domain in complex with 1-{4-[(2r)-1-(5- chloro-2,4-dihydroxybenzoyl)pyrrolidin-2-yl]benzyl}-3,3- difluoropyrrolidinium
3hhu		Human heat-shock protein 90 (hsp90) in complex with {4-[3- (2,4-dihydroxy-5-isopropyl-phenyl)-5-thioxo- 1,5-dihydro- [1,2,4]triazol-4-yl]-benzyl}-carbamic acid ethyl ester {zk 2819}
3ied		Crystal structure of n-terminal domain of plasmodium falciparum hsp90 (pf14_0417) in complex with amppn

Links (links to other resources describing this domain)
INTERPRO IPR003594