HRDC

Helicase and RNase D C-terminal
HRDC
SMART accession number:SM00341
Description: Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Interpro abstract (IPR002121): The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [(PUBMED:9397680)].
GO component:intracellular (GO:0005622)
GO function:nucleic acid binding (GO:0003676)
Family alignment:
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There are 1443 HRDC domains in 1360 proteins in SMART's nrdb database.

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