HTH_DTXR

Helix-turn-helix diphteria tox regulatory element
HTH_DTXR
SMART accession number:SM00529
Description: iron dependent repressor
Interpro abstract (IPR022689): The diphtheria toxin repressor protein (DTXR) is a member of this group [(PUBMED:7568230)]. In Corynebacterium diphtheriae where it has been studied in some detail this protein acts as an iron-binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. The N terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation [(PUBMED:7743135)].
GO process:regulation of transcription, DNA-dependent (GO:0006355)
GO function:transition metal ion binding (GO:0046914), sequence-specific DNA binding transcription factor activity (GO:0003700)
Family alignment:
View or

There are 994 HTH_DTXR domains in 994 proteins in SMART's nrdb database.

Click on the following links for more information.