• Links (links to other resources describing this domain)
  • HintN

    Hint (Hedgehog/Intein) domain N-terminal region
    SMART accession number:SM00306
    Description: Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.
    Interpro abstract (IPR003587):

    Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [(PUBMED:9489693)].

    This entry represents the N-terminal region of the hint domain.
    Family alignment:
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    There are 2967 HintN domains in 2708 proteins in SMART's nrdb database.

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