Hr1Rho effector or protein kinase C-related kinase homology region 1 homologues
|SMART accession number:||SM00742|
|Description:||Alpha-helical domain found in vertebrate PRK1 and yeast PKC1 protein kinases C. The HR1 in rhophilin bind RhoGTP; those in PRK1 bind RhoA and RhoB. Also called RBD - Rho-binding domain|
|Interpro abstract (IPR011072):|
The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [(PUBMED:7851406)]. The first two of these repeats were later shown to bind the small G protein rho [(PUBMED:8647255), (PUBMED:9446575)] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [(PUBMED:10619026)]. It forms an antiparallel coiled-coil fold termed an ACC finger.
|GO process:||signal transduction (GO:0007165)|
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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