This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus (PMID:8975715). Its precise function is unknown.
This entry represents a C-terminal domain found in islet cell autoantigen Ica1. Ica1 has been identified as an islet cell autoantigen in type I diabetes mellitus [ (PUBMED:8975715) ]. Its precise function is unknown, though it may play a role in neurotransmitter secretion [ (PUBMED:11029035) ].
Family alignment:
There are 1020 ICA69 domains in 1020 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing ICA69 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with ICA69 domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing ICA69 domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Genomic organization and transcript analysis of ICAp69, a target antigen indiabetic autoimmunity.
Genomics. 1996; 38: 382-91
Display abstract
Islet cell antigen p69 (ICAp69) is a target self-antigen in autoimmune(insulin-dependent) diabetes mellitus. Distributed over more than 100 kb onchromosome 6 (6{A1-A2}), the single murine genomic locus contains 14 codingexons, 39-271 bp in length. The identified human and mouse intron-exon junctions are identical, with intron sizes ranging from 94 bp to 24 kb and with conservedflanking region intron sequences. cDNA cloning identified alternatively splicedICAp69 mRNA transcripts. The predominating alpha-transcripts lack exon 4, whilebeta-transcripts include this exon, which codes translation termination in allreading frames and a truncated molecule following in vitro expression.gamma-Transcripts show splice removal of exons 8-12, while delta-transcriptsexclude exon 11. Transcripts use alternative polyadenylation signals including a less frequent ATTAAA sequence. 5'-Untranslated cDNA and genomic sequencing andlong PCR analysis suggest the presence of more noncoding exons. All splicevariants encode the conserved T-cell epitope (in exon 2) recognized byautoreactive T cells in diabetic children and diabetes-prone NOD mice.
Links (links to other resources describing this domain)
