JAB_MPN

JAB/MPN domain
JAB_MPN
SMART accession number:SM00232
Description: Domain in Jun kinase activation domain binding protein and proteasomal subunits. Domain at Mpr1p and Pad1p N-termini. Domain of unknown function.
Interpro abstract (IPR000555):

This domain is known as the MPN domain [(PUBMED:9644972)], PAD-1-like domain [(PUBMED:10369758)], JABP1 domain [(PUBMED:20838651)] or JAMM domain [(PUBMED:12183636)]. Proteins with this domain include proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. They are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes [(PUBMED:12183636)]. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role [(PUBMED:16859499)].

The archaeal (H. volcanii) JAMM domain containing protein, HvJAMM1, cleaves ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates [(PUBMED:22970855)]. The bacterial JAMM domain containing protein QbsD from Pseudomonas fluorescens cleaves the C-terminal amino acid residues of the sulfur carrier protein QbsE prior to the formation of the carboxy-terminal thiocarboxylate [(PUBMED:17209031)].

GO function:protein binding (GO:0005515)
Family alignment:
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There are 6342 JAB_MPN domains in 6338 proteins in SMART's nrdb database.

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