Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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JAB_MPN JAB/MPN domain

SMART accession number:	SM00232
Description:	Domain in Jun kinase activation domain binding protein and proteasomal subunits. Domain at Mpr1p and Pad1p N-termini. Domain of unknown function.
Interpro abstract (IPR000555):	This domain is known as the MPN domain [(PUBMED:9644972)], PAD-1-like domain [(PUBMED:10369758)], JABP1 domain [(PUBMED:20838651)] or JAMM domain [(PUBMED:12183636)]. Proteins with this domain include proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. They are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes [(PUBMED:12183636)]. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role [(PUBMED:16859499)].
GO function:	protein binding (GO:0005515)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 2036 JAB_MPN domains in 2036 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a JAB_MPN domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with JAB_MPN domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Aravind L, Ponting CP
  • Homologues of 26S proteasome subunits are regulators of transcription and translation.
  • Protein Sci. 1998; 7: 1250-4
  • Display abstract

  • Single copies of an alpha-helical-rich motif are demonstrated to be present within subunits of the large multiprotein 26S proteasome and eukaryotic initiation factor-3 (eIF3) complexes, and within proteins involved in transcriptional regulation. In addition, p40 and p47 subunits of eIF3 are shown to be homologues of the proteasome subunit Mov34, and transcriptional regulators JAB1/pad1. Finally, the proteasome subunit S5a and the p44 subunit of the basal transcription factor IIH (TFIIH) are identified as homologues. The presence of homologous, and sometimes identical, proteins in contrasting functional contexts suggests that the large multisubunit complexes of the 26S proteasome, eIF3 and TFIIH perform overlapping cellular roles.

  • Hofmann K, Bucher P
  • The PCI domain: a common theme in three multiprotein complexes.
  • Trends Biochem Sci. 1998; 23: 204-5
• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 95.35 map03050 Proteasome 2.33 map00780 Biotin metabolism 2.33 map00310 Lysine degradation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with JAB_MPN domain which could be assigned to a KEGG orthologous group, and not all proteins containing JAB_MPN domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of JAB_MPN domains in PDB

  PDB code	Main view	Title
  1oi0		Crystal structure of af2198, a jab1/mpn domain protein from archaeoglobus fulgidus
  1r5x		Jamm: a metalloprotease-like zinc site in the proteasome and signalosome
  2kcq		Solution structure of protein sru_2040 from salinibacter ruber (strain dsm 13855) . northeast structural genomics consortium target srr106
  2kks		Solution structure of protein dsy2949 from desulfitobacterium hafniense. northeast structural genomics consortium target dhr27
  2o95		Crystal structure of the metal-free dimeric human mov34 mpn domain (residues 1-186)
  2o96		Crystal structure of the metal-free dimeric human mov34 mpn domain (residues 1-177)
  2og4		Structure of an expanded jab1-mpn-like domain of splicing factor prp8p from yeast
  2p87		Crystal structure of the c-terminal domain of c. elegans pre-mrna splicing factor prp8
  2p8r		Crystal structure of the c-terminal domain of c. elegans pre-mrna splicing factor prp8 carrying r2303k mutant
  2znr		Crystal structure of the dub domain of human amsh-lp
  2znv		Crystal structure of human amsh-lp dub domain in complex with lys63-linked ubiquitin dimer

• Links (links to other resources describing this domain)

• INTERPRO	IPR000555

Send comments to Ivica Letunic