Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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JmjN Small domain found in the jumonji family of transcription factors

SMART accession number:	SM00545
Description:	To date, this domain always co-occurs with the JmjC domain (although the reverse is not true).
Interpro abstract (IPR003349):	Jumonji protein is required for neural tube formation in mice [(PUBMED:7758946)].There is evidence of domain swapping within the jumonji family of transcription factors [(PUBMED:10838566)]. This domain is often associated with JmjC (see IPR003347).
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 556 JmjN domains in 556 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a JmjN domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with JmjN domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Balciunas D, Ronne H
  • Evidence of domain swapping within the jumonji family of transcription factors.
  • Trends Biochem Sci. 2000; 25: 274-6
• Structure (3D structures containing this domain)

• 3D Structures of JmjN domains in PDB

  PDB code	Main view	Title
  2gp3		Crystal structure of the catalytic core domain of jmjd2a
  2gp5		Crystal structure of catalytic core domain of jmjd2a complexed with alpha-ketoglutarate
  2oq6		Crystal structure of jmjd2a complexed with histone h3 peptide trimethylated at lys9
  2oq7		The crystal structure of jmjd2a complexed with ni and n- oxalylglycine
  2os2		Crystal structure of jmjd2a complexed with histone h3 peptide trimethylated at lys36
  2ot7		Crystal structure of jmjd2a complexed with histone h3 peptide monomethylated at lys9
  2ox0		Crystal structure of jmjd2a complexed with histone h3 peptide dimethylated at lys9
  2p5b		The complex structure of jmjd2a and trimethylated h3k36 peptide
  2pxj		The complex structure of jmjd2a and monomethylated h3k36 peptide
  2q8c		Crystal structure of jmjd2a in ternary complex with an histone h3k9me3 peptide and 2-oxoglutarate
  2q8d		Crystal structure of jmj2d2a in ternary complex with histone h3-k36me2 and succinate
  2q8e		Specificity and mechanism of jmjd2a, a trimethyllysine- specific histone demethylase
  2vd7		Crystal structure of jmjd2a complexed with inhibitor pyridine-2,4-dicarboxylic acid
  2w2i		Crystal structure of the human 2-oxoglutarate oxygenase loc390245
  3dxt		Crystal structure of the catalytic core domain of jmjd2d
  3dxu		The crystal structure of core jmjd2d complexed with fe and n-oxalylglycine

• Links (links to other resources describing this domain)

• INTERPRO	IPR003349

Send comments to Ivica Letunic