KOWKOW (Kyprides, Ouzounis, Woese) motif. |
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| SMART accession number: | SM00739 |
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| Description: | Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54. |
| Interpro abstract (IPR005824): | Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [(PUBMED:11297922), (PUBMED:11290319)]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [(PUBMED:11290319), (PUBMED:11114498)]. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and the bacterial transcription antitermination proteins NusG [(PUBMED:8987397)]. |
| Family alignment: |
There are 4720 KOW domains in 3869 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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to expand nodes. To display all proteins with a KOW domain in a specific node, click on it.This tree shows only several representative species. The complete taxonomic breakdown of all proteins with KOW domain is also avaliable.
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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes - Cellular role (predicted cellular role)
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Cellular role: chromatin, translation, transcription
Binding / catalysis: Possible RNA-binding - Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Steiner T, Kaiser JT, Marinkovic S, Huber R, Wahl MC
- Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities.
- EMBO J. 2002; 21: 4641-4653
- Display abstract
Microbial transcription modulator NusG interacts with RNA polymerase and termination factor rho, displaying striking functional homology to eukaryotic Spt5. The protein is also a translational regulator. We have determined crystal structures of Aquifex aeolicus NusG showing a modular design: an N-terminal RNP-like domain, a C-terminal element with a KOW sequence motif and a species-specific immunoglobulin-like fold. The structures reveal bona fide nucleic acid binding sites, and nucleic acid binding activities can be detected for NusG from three organisms and for the KOW element alone. A conserved KOW domain is defined as a new class of nucleic acid binding folds. This module is a close structural homolog of tudor protein-protein interaction motifs. Putative protein binding sites for the RNP and KOW domains can be deduced, which differ from the areas implicated in nucleic acid interactions. The results strongly argue that both protein and nucleic acid contacts are important for NusG's functions and that the factor can act as an adaptor mediating indirect protein-nucleic acid associations.
- Kyrpides NC, Woese CR, Ouzounis CA
- KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins.
- Trends Biochem Sci. 1996; 21: 425-6
- Metabolism (metabolic pathways involving proteins which contain this domain)
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% proteins involved KEGG pathway ID Description 100.00 map03010 Ribosome This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with KOW domain which could be assigned to a KEGG orthologous group, and not all proteins containing KOW domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of KOW domains in PDB
PDB code Main view Title 1ffk 
Crystal structure of the large ribosomal subunit from haloarcula marismortui at 2.4 angstrom resolution 1giy 
Crystal structure of the ribosome at 5.5 a resolution. this file, 1giy, contains the 50s ribosome subunit. the 30s ribosome subunit, three trna, and mrna molecules are in the file 1gix 1jj2 
Fully refined crystal structure of the haloarcula marismortui large ribosomal subunit at 2.4 angstrom resolution 1k73 
Co-crystal structure of anisomycin bound to the 50s ribosomal subunit 1k8a 
Co-crystal structure of carbomycin a bound to the 50s ribosomal subunit of haloarcula marismortui 1k9m 
Co-crystal structure of tylosin bound to the 50s ribosomal subunit of haloarcula marismortui 1kc8 
Co-crystal structure of blasticidin s bound to the 50s ribosomal subunit 1kd1 
Co-crystal structure of spiramycin bound to the 50s ribosomal subunit of haloarcula marismortui 1kqs 
The haloarcula marismortui 50s complexed with a pretranslocational intermediate in protein synthesis 1m1g 
Crystal structure of aquifex aeolicus n-utilization substance g (nusg), space group p2(1) 1m1h 
Crystal structure of aquifex aeolicus n-utilization substance g (nusg), space group i222 1m1k 
Co-crystal structure of azithromycin bound to the 50s ribosomal subunit of haloarcula marismortui 1m90 
Co-crystal structure of cca-phe-caproic acid-biotin and sparsomycin bound to the 50s ribosomal subunit 1n8r 
Structure of large ribosomal subunit in complex with virginiamycin m 1nji 
Structure of chloramphenicol bound to the 50s ribosomal subunit 1nkw 
Crystal structure of the large ribosomal subunit from deinococcus radiodurans 1npp 
Crystal structure of aquifex aeolicus nusg in p2(1) 1npr 
Crystal structure of aquifex aeolicus nusg in c222(1) 1nwx 
Complex of the large ribosomal subunit from deinococcus radiodurans with abt-773 1nwy 
Complex of the large ribosomal subunit from deinococcus radiodurans with azithromycin 1nz9 
Solution structure of the n-utilisation substance g (nusg) c-terminal (ngc) domain from thermus thermophilus 1p85 
Real space refined coordinates of the 50s subunit fitted into the low resolution cryo-em map of the ef-g.gtp state of e. coli 70s ribosome 1p86 
Real space refined coordinates of the 50s subunit fitted into the low resolution cryo-em map of the initiation-like state of e. coli 70s ribosome 1pnu 
Crystal structure of a streptomycin dependent ribosome from escherichia coli, 50s subunit of 70s ribosome. this file, 1pnu, contains only molecules of the 50s ribosomal subunit. the 30s subunit, mrna, p-site trna, and a-site trna are in the pdb file 1pns. 1pny 
Crystal structure of the wild type ribosome from e. coli, 50s subunit of 70s ribosome. this file, 1pny, contains only molecules of the 50s ribosomal subunit. the 30s subunit is in the pdb file 1pnx. 1q7y 
Crystal structure of ccdap-puromycin bound at the peptidyl transferase center of the 50s ribosomal subunit 1q81 
Crystal structure of minihelix with 3' puromycin bound to a- site of the 50s ribosomal subunit. 1q82 
Crystal structure of cc-puromycin bound to the a-site of the 50s ribosomal subunit 1q86 
Crystal structure of cca-phe-cap-biotin bound simultaneously at half occupancy to both the a-site and p- site of the the 50s ribosomal subunit. 1qvf 
Structure of a deacylated trna minihelix bound to the e site of the large ribosomal subunit of haloarcula marismortui 1qvg 
Structure of cca oligonucleotide bound to the trna binding sites of the large ribosomal subunit of haloarcula marismortui 1s1i 
Structure of the ribosomal 80s-eef2-sordarin complex from yeast obtained by docking atomic models for rna and protein components into a 11.7 a cryo-em map. this file, 1s1i, contains 60s subunit. the 40s ribosomal subunit is in file 1s1h. 1s72 
Refined crystal structure of the haloarcula marismortui large ribosomal subunit at 2.4 angstrom resolution 1sm1 
Complex of the large ribosomal subunit from deinococcus radiodurans with quinupristin and dalfopristin 1vor 
Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400. 1vou 
Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400. 1vow 
Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400. 1voy 
Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400. 1vp0 
Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400. 1vq4 
The structure of the transition state analogue "daa" bound to the large ribosomal subunit of haloarcula marismortui 1vq5 
The structure of the transition state analogue "raa" bound to the large ribosomal subunit of haloarcula marismortui 1vq6 
The structure of c-hpmn and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui 1vq7 
The structure of the transition state analogue "dca" bound to the large ribosomal subunit of haloarcula marismortui 1vq8 
The structure of ccda-phe-cap-bio and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui 1vq9 
The structure of cca-phe-cap-bio and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui 1vqk 
The structure of ccda-phe-cap-bio bound to the a site of the ribosomal subunit of haloarcula marismortui 1vql 
The structure of the transition state analogue "dcsn" bound to the large ribosomal subunit of haloarcula marismortui 1vqm 
The structure of the transition state analogue "dan" bound to the large ribosomal subunit of haloarcula marismortui 1vqn 
The structure of cc-hpmn and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui 1vqo 
The structure of ccpmn bound to the large ribosomal subunit haloarcula marismortui 1vqp 
The structure of the transition state analogue "rap" bound to the large ribosomal subunit of haloarcula marismortui 1vs6 
Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 1vs8 
Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 1vsa 
Crystal structure of a 70s ribosome-trna complex reveals functional interactions and rearrangements. this file, 1vsa, contains the 50s ribosome subunit. 30s ribosome subunit is in the file 2ow8 1vsp 
Interactions and dynamics of the shine-dalgarno helix in the 70s ribosome. this file, 1vsp, contains the 50s ribosome subunit. 30s ribosome subunit is in the file 2qnh 1w2b 
Trigger factor ribosome binding domain in complex with 50s 1xbp 
Inhibition of peptide bond formation by pleuromutilins: the structure of the 50s ribosomal subunit from deinococcus radiodurans in complex with tiamulin 1yhq 
Crystal structure of azithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui 1yi2 
Crystal structure of erythromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui 1yij 
Crystal structure of telithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui 1yit 
Crystal structure of virginiamycin m and s bound to the 50s ribosomal subunit of haloarcula marismortui 1yj9 
Crystal structure of the mutant 50s ribosomal subunit of haloarcula marismortui containing a three residue deletion in l22 1yjn 
Crystal structure of clindamycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui 1yjw 
Crystal structure of quinupristin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui 1yl3 
Crystal structure of 70s ribosome with thrs operator and trnas. large subunit. the coordinates for the small subunit are in the pdb entry 1yl4. 2aw4 
Crystal structure of the bacterial ribosome from escherichia coli at 3.5 a resolution. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2awb 
Crystal structure of the bacterial ribosome from escherichia coli at 3.5 a resolution. this file contains the 50s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2b66 
50s ribosomal subunit from a crystal structure of release factor rf1, trnas and mrna bound to the ribosome. this file contains the 50s subunit from a crystal structure of release factor rf1, trnas and mrna bound to the ribosome and is described in remark 400 2b9n 
50s ribosomal subunit from a crystal structure of release factor rf2, trnas and mrna bound to the ribosome. this file contains the 50s subunit from a crystal structure of release factor rf1, trnas and mrna bound to the ribosome and is described in remark 400. 2b9p 
50s ribosomal subunit from a crystal structure of the ribosome in complex with trnas and mrna with a stop codon in the a-site. this file contains the 50s subunit from a crystal structure of the ribosome in complex with trnas and mrna with a stop codon in the a-site and is described in remark 400. 2ckk 
High resolution crystal structure of the human kin17 c-terminal domain containing a kow motif kin17. 2d3o 
Structure of ribosome binding domain of the trigger factor on the 50s ribosomal subunit from d. radiodurans 2do3 
Solution structure of the third kow motif of transcription elongation factor spt5 2e6z 
Solution structure of the second kow motif of human transcription elongation factor spt5 2e70 
Solution structure of the fifth kow motif of human transcription elongation factor spt5 2ftc 
Structural model for the large subunit of the mammalian mitochondrial ribosome 2gya 
Structure of the 50s subunit of a pre-translocational e. coli ribosome obtained by fitting atomic models for rna and protein components into cryo-em map emd-1056 2gyc 
Structure of the 50s subunit of a secm-stalled e. coli ribosome complex obtained by fitting atomic models for rna and protein components into cryo-em map emd-1143 2hgj 
Crystal structure of the 70s thermus thermophilus ribosome showing how the 16s 3'-end mimicks mrna e and p codons. this entry 2hgj contains 50s ribosomal subunit. the 30s ribosomal subunit can be found in pdb entry 2hgi. 2hgq 
Crystal structure of the 70s thermus thermophilus ribosome with translocated and rotated shine-dalgarno duplex. this entry 2hgq contains 50s ribosomal subunit. the 30s ribosomal subunit can be found in pdb entry 2hgp. 2hgu 
70s t.th. ribosome functional complex with mrna and e- and p-site trnas at 4.5a. this entry 2hgu contains 50s ribosomal subunit. the 30s ribosomal subunit can be found in pdb entry 2hgr. 2i2t 
Crystal structure of ribosome with messenger rna and the anticodon stem-loop of p-site trna. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2i2v 
Crystal structure of ribosome with messenger rna and the anticodon stem-loop of p-site trna. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2j01 
Structure of the thermus thermophilus 70s ribosome complexed with mrna, trna and paromomycin (part 2 of 4). this file contains the 50s subunit from molecule i. 2j03 
Structure of the thermus thermophilus 70s ribosome complexed with mrna, trna and paromomycin (part 4 of 4). this file contains the 50s subunit from molecule ii. 2j28 
Model of e. coli srp bound to 70s rncs 2jvv 
Solution structure of e. coli nusg carboxyterminal domain 2otj 
13-deoxytedanolide bound to the large subunit of haloarcula marismortui 2otl 
Girodazole bound to the large subunit of haloarcula marismortui 2oug 
Crystal structure of the rfah transcription factor at 2.1a resolution 2qa4 
A more complete structure of the the l7/l12 stalk of the haloarcula marismortui 50s large ribosomal subunit 2qam 
Crystal structure of the bacterial ribosome from escherichia coli in complex with neomycin. this file contains the 50s subunit of the first 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qao 
Crystal structure of the bacterial ribosome from escherichia coli in complex with neomycin. this file contains the 50s subunit of the second 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qba 
Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin. this file contains the 50s subunit of the first 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qbc 
Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin. this file contains the 50s subunit of the second 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qbe 
Crystal structure of the bacterial ribosome from escherichia coli in complex with ribosome recycling factor (rrf). this file contains the 50s subunit of the first 70s ribosome, with rrf bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qbg 
Crystal structure of the bacterial ribosome from escherichia coli in complex with ribosome recycling factor (rrf). this file contains the 50s subunit of the second 70s ribosome, with rrf bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qbi 
Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin and ribosome recycling factor (rrf). this file contains the 50s subunit of the first 70s ribosome, with gentamicin and rrf bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qbk 
Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin and ribosome recycling factor (rrf). this file contains the 50s subunit of the second 70s ribosome, with gentamicin and rrf bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2qex 
Negamycin binds to the wall of the nascent chain exit tunnel of the 50s ribosomal subunit 2qov 
Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin. this file contains the 50s subunit of the first 70s ribosome. the entire crystal structure contains two 70s ribosomes. 2qox 
Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin. this file contains the 50s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes. 2qoz 
Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin and neomycin. this file contains the 50s subunit of the first 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes. 2qp1 
Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin and neomycin. this file contains the 50s subunit of the second 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes. 2rdo 
50s subunit with ef-g(gdpnp) and rrf bound 2v47 
Structure of the ribosome recycling factor bound to the thermus thermophilus 70s ribosome with mrna, asl-phe and trna-fmet (part 2 of 4). this file contains the 50s subunit for molecule 1. 2v49 
Structure of the ribosome recycling factor bound to the thermus thermophilus 70s ribosome with mrna, asl-phe and trna-fmet (part 4 of 4). this file contains the 50s subunit of molecule 2. 2vhm 
Structure of pdf binding helix in complex with the ribosome (part 1 of 4) 2vhn 
Structure of pdf binding helix in complex with the ribosome. (part 2 of 4) 2vrh 
Structure of the e. coli trigger factor bound to a translating ribosome 2wdi 
Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a-site trna, deacylated p-site trna, and e-site trna. this file contains the 50s subunit for molecule i. 2wdj 
Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a-site trna, deacylated p-site trna, and e-site trna. this file contains the 50s subunit for molecule ii. 2wdl 
Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a- and p-site trnas, and e-site trna. this file contains the 50s subunit for molecule i. 2wdn 
Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a- and p-site trnas, and e-site trna. this file contains the 50s subunit for molecule ii. 2wh2 
Insights into translational termination from the structure of rf2 bound to the ribosome 2wh4 
Insights into translational termination from the structure of rf2 bound to the ribosome 2wrj 
The structure of the ribosome with elongation factor g trapped in the post-translocational state (part 2 of 4). 2wrl 
The structure of the ribosome with elongation factor g trapped in the post-translocational state. (part 4 of 4). 2wro 
The crystal structure of the 70s ribosome bound to ef-tu and trna (part 2 of 4). 2wrr 
The crystal structure of the 70s ribosome bound to ef-tu and trna (part 4 of 4). 2z4l 
Crystal structure of the bacterial ribosome from escherichia coli in complex with paromomycin and ribosome recycling factor (rrf). this file contains the 50s subunit of the first 70s ribosome, with paromomycin and rrf bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2z4n 
Crystal structure of the bacterial ribosome from escherichia coli in complex with paromomycin and ribosome recycling factor (rrf). this file contains the 50s subunit of the second 70s ribosome, with paromomycin and rrf bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400. 2zjp 
Thiopeptide antibiotic nosiheptide bound to the large ribosomal subunit of deinococcus radiodurans 2zjq 
Interaction of l7 with l11 induced by microccocin binding to the deinococcus radiodurans 50s subunit 2zjr 
Refined native structure of the large ribosomal subunit (50s) from deinococcus radiodurans 2zkr 
Structure of a mammalian ribosomal 60s subunit within an 80s complex obtained by docking homology models of the rna and proteins into an 8.7 a cryo-em map 3bbo 
Homology model for the spinach chloroplast 50s subunit fitted to 9.4a cryo-em map of the 70s chlororibosome 3bbx 
The hsp15 protein fitted into the low resolution cryo-em map of the 50s.nc-trna.hsp15 complex 3cc2 
The refined crystal structure of the haloarcula marismortui large ribosomal subunit at 2.4 angstrom resolution with rrna sequence for the 23s rrna and genome-derived sequences for r-proteins 3cc4 
Co-crystal structure of anisomycin bound to the 50s ribosomal subunit 3cc7 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation c2487u 3cce 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation u2535a 3ccj 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation c2534u 3ccl 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation u2535c. density for anisomycin is visible but not included in model. 3ccm 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2611u 3ccq 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation a2488u 3ccr 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation a2488c. density for anisomycin is visible but not included in the model. 3ccs 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2482a 3ccu 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2482c 3ccv 
Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2616a 3cd6 
Co-cystal of large ribosomal subunit mutant g2616a with cc- puromycin 3cf5 
Thiopeptide antibiotic thiostrepton bound to the large ribosomal subunit of deinococcus radiodurans 3cma 
The structure of cca and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui 3cme 
The structure of ca and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui 3cpw 
The structure of the antibiotic linezolid bound to the large ribosomal subunit of haloarcula marismortui 3cxc 
The structure of an enhanced oxazolidinone inhibitor bound to the 50s ribosomal subunit of h. marismortui 3d5b 
Structural basis for translation termination on the 70s ribosome. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400. 3d5d 
Structural basis for translation termination on the 70s ribosome. this file contains the 50s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400. 3df2 
Crystal structure of the bacterial ribosome from escherichia coli in complex with hygromycin b. this file contains the 50s subunit of the first 70s ribosome. the entire crystal structure contains two 70s ribosomes. 3df4 
Crystal structure of the bacterial ribosome from escherichia coli in complex with hygromycin b. this file contains the 50s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes. 3dll 
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect trna positioning 3e1b 
Structure of the 50s subunit of e. coli ribosome in pre- accommodation state 3e1d 
Structure of the 50s subunit of e. coli ribosome in post- accommodation state 3f1f 
Crystal structure of a translation termination complex formed with release factor rf2. this file contains the 50s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400. 3f1h 
Crystal structure of a translation termination complex formed with release factor rf2. this file contains the 50s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400. 3fik 
Ternary complex-bound e.coli 70s ribosome. this entry consists of the 50s subunit. 3fin 
T. thermophilus 70s ribosome in complex with mrna, trnas and ef-tu.gdp.kirromycin ternary complex, fitted to a 6.4 a cryo-em map. this file contains the 50s subunit. 3g4s 
Co-crystal structure of tiamulin bound to the large ribosomal subunit 3g6e 
Co-crystal structure of homoharringtonine bound to the large ribosomal subunit 3g71 
Co-crystal structure of bruceantin bound to the large ribosomal subunit 3hux 
Structure of ef-p bound to the 70s ribosome; this file contains the 50s subunit for molecule i. 3huz 
Structure of ef-p bound to the 70s ribosome; this file contains the 50s subunit for molecule ii. 3i1n 
Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting 3i1p 
Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting 3i1r 
Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting 3i1t 
Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting 3i20 
Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting 3i22 
Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting 3iy9 
Leishmania tarentolae mitochondrial large ribosomal subunit model - Links (links to other resources describing this domain)
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PFAM KOW INTERPRO IPR005824