Knot1Knottins |
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| SMART accession number: | SM00505 |
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| Description: | Knottins, representing plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins and arthropod defensins. |
| Interpro abstract (IPR003614): | Knottins are small proteins characterised by a cystine-knot [ (PUBMED:18025039) ]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins [ (PUBMED:15551519) ]. The scorpion toxin-like domain is found in a subgroup of metazoan knottins mainly from the arthropoda, which include the antibacterial defensins [ (PUBMED:8380707) ] and the scorpion alpha-neurotoxins [ (PUBMED:12925796) ]. The plant sequences include members of the gamma-thionin family, which are plant defensins that have no antifungal activity. Other members are insect alpha-amylase inhibitors, cysteine-rich antifungal proteins and proteins annotated as proteinase inhibitors; those that are characterised belong to MEROPS inhibitor family I18, clan I. |
| GO process: | defense response (GO:0006952) |
| Family alignment: |
There are 3746 Knot1 domains in 3435 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing Knot1 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Knot1 domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing Knot1 domain in the selected taxonomic class.
- Structure (3D structures containing this domain)
3D Structures of Knot1 domains in PDB
PDB code Main view Title 1aho 
THE AB INITIO STRUCTURE DETERMINATION AND REFINEMENT OF A SCORPION PROTEIN TOXIN 1ayj 
DETERMINATION OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF RAPHANUS SATIVUS ANTIFUNGAL PROTEIN 1 (RS-AFP1) BY 1H NMR, 20 STRUCTURES 1b3c 
SOLUTION STRUCTURE OF A BETA-NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING 1b7d 
NEUROTOXIN (TS1) FROM BRAZILIAN SCORPION TITYUS SERRULATUS 1bcg 
SCORPION TOXIN BJXTR-IT 1bk8 
DETERMINATION OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF AESCULUS HIPPOCASTANUM ANTIMICROBIAL PROTEIN 1 (AH-AMP1) BY 1H NMR, 25 STRUCTURES 1bmr 
ALPHA-LIKE TOXIN LQH III FROM SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, 25 STRUCTURES 1chz 
A NEW NEUROTOXIN FROM BUTHUS MARTENSII KARSCH 1cn2 
SOLUTION STRUCTURE OF TOXIN 2 FROM CENTRUROIDES NOXIUS HOFFMANN, A BETA SCORPION NEUROTOXIN ACTING ON SODIUM CHANNELS, NMR, 15 STRUCTURES 1djt 
ATOMIC RESOLUTION STRUCTURE OF SCORPION ALPHA-LIKE TOXIN BMK M1 IN A NEW CRYSTAL FORM 1dq7 
THREE-DIMENSIONAL STRUCTURE OF A NEUROTOXIN FROM RED SCORPION (BUTHUS TAMULUS) AT 2.2A RESOLUTION. 1fh3 
NMR STRUCTURES OF LQH III ALPHA-LIKE SCORPION TOXIN FROM LEIURUS QUINQUESTRIATUS CORRESPONDING TO THE MAJOR CONFORMER IN SOLUTION 1gps 
SOLUTION STRUCTURE OF GAMMA 1-H AND GAMMA 1-P THIONINS FROM BARLEY AND WHEAT ENDOSPERM DETERMINED BY 1H-NMR: A STRUCTURAL MOTIF COMMON TO TOXIC ARTHROPOD PROTEINS 1gpt 
SOLUTION STRUCTURE OF GAMMA 1-H AND GAMMA 1-P THIONINS FROM BARLEY AND WHEAT ENDOSPERM DETERMINED BY 1H-NMR: A STRUCTURAL MOTIF COMMON TO TOXIC ARTHROPOD PROTEINS 1i6f 
NMR SOLUTION STRUCTURE OF THE INSECT-SPECIFIC NEUROTOXIN VARIANT 5 (CSE-V5) FROM THE SCORPION CENTRUROIDES SCULPTURATUS EWING 1i6g 
NMR SOLUTION STRUCTURE OF THE INSECT-SPECIFIC NEUROTOXIN VARIANT 5 (CSE-V5) FROM THE SCORPION CENTRUROIDES SCULPTURATUS EWING 1ica 
REFINED THREE-DIMENSIONAL STRUCTURE OF INSECT DEFENSIN A 1jkz 
NMR Solution Structure of Pisum sativum defensin 1 (Psd1) 1jxc 
Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor 1jza 
Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing 1jzb 
Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing 1kv0 
Cis/trans Isomerization of Non-prolyl Peptide Bond Observed in Crystal Structure of an Scorpion Toxin 1l4v 
SOLUTION STRUCTURE OF SAPECIN 1lqh 
INSECTICIDAL ALPHA SCORPION TOXIN ISOLATED FROM THE VENOM OF SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, MINIMIZED AVERAGE STRUCTURE 1lqi 
INSECTICIDAL ALPHA SCORPION TOXIN ISOLATED FROM THE VENOM OF SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, 29 STRUCTURES 1lqq 
ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES 1mr4 
Solution Structure of NaD1 from Nicotiana alata 1myn 
SOLUTION STRUCTURE OF DROSOMYCIN, THE FIRST INDUCIBLE ANTIFUNGAL PROTEIN FROM INSECTS, NMR, 15 STRUCTURES 1n4n 
Structure of the Plant Defensin PhD1 from Petunia Hybrida 1nh5 
AUTOMATIC ASSIGNMENT OF NMR DATA AND DETERMINATION OF THE PROTEIN STRUCTURE OF A NEW WORLD SCORPION NEUROTOXIN USING NOAH/DIAMOD 1npi 
Tityus Serrulatus Neurotoxin (Ts1) at atomic resolution 1nra 
SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING 1nrb 
SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING 1omy 
Crystal Structure of a Recombinant alpha-insect Toxin BmKaIT1 from the scorpion Buthus martensii Karsch 1ozz 
NMR structure of antifungal defensin ARD1 from Archaeoprepona demophon 1p00 
NMR structure of ETD151, mutant of the antifungal defensin ARD1 from Archaeoprepona demophon 1p0a 
NMR structure of ETD135, mutant of the antifungal defensin ARD1 from Archaeoprepona demophon 1pe4 
SOLUTION STRUCTURE OF TOXIN CN12 FROM CENTRUROIDES NOXIUS ALFA SCORPION TOXIN ACTING ON SODIUM CHANNELS. NMR STRUCTURE 1ptx 
CRYSTAL STRUCTURE OF TOXIN II FROM THE SCORPION ANDROCTONUS AUSTRALIS HECTOR REFINED AT 1.3 ANGSTROMS RESOLUTION 1seg 
Crystal structure of a toxin chimera between Lqh-alpha-IT from the scorpion Leiurus quinquestriatus hebraeus and AAH2 from Androctonus australis hector 1sn1 
STRUCTURE OF SCORPION NEUROTOXIN BMK M1 1sn4 
STRUCTURE OF SCORPION NEUROTOXIN BMK M4 1snb 
STRUCTURE OF SCORPION NEUROTOXIN BMK M8 1t0z 
Structure of an Excitatory Insect-specific Toxin with an Analgesic Effect on Mammalian from Scorpion Buthus martensii Karsch 1t1t 
Solution Structure of Kurtoxin 1t7a 
Crystal structure of mutant Lys8Asp of scorpion alpha-like neurotoxin BmK M1 from Buthus martensii Karsch 1t7b 
Crystal structure of mutant Lys8Gln of scorpion alpha-like neurotoxin BmK M1 from Buthus martensii Karsch 1t7e 
Crystal structure of mutant Pro9Ser of scorpion alpha-like neurotoxin BmK M1 from Buthus martensii Karsch 1ti5 
Solution structure of plant defensin 1vna 
PROTON NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY(SLASH)SIMULATED ANNEALING STUDIES ON THE VARIANT-1 NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING 1vnb 
PROTON NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY(SLASH)SIMULATED ANNEALING STUDIES ON THE VARIANT-1 NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING 1wwn 
NMR Solution Structure of BmK-betaIT, an Excitatory Scorpion Toxin from Buthus martensi Karsch 1zu3 
Crystal Structure Of Mutant K8A Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch 1zut 
Crystal Structure Of Mutant K8DP9SR58K Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch 1zve 
Crystal Structure Of Mutant K8G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch 1zvg 
Crystal Structure Of Mutant K8DP9S Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch 1zyv 
Crystal Structure Of Mutant K8DP9SR58KV59G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch 1zyw 
Crystal Structure Of Mutant K8DP9SR58KP60G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch 2a7t 
Crystal Structure of a novel neurotoxin from Buthus tamalus at 2.2A resolution. 2asc 
Scorpion toxin LQH-alpha-IT 2atb 
Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT 2b3c 
SOLUTION STRUCTURE OF A BETA-NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING 2e0h 
Solution Structure of BmKalphaIT01, an alpha-insect toxin from the Venom of the Chinese Scorpion Buthus martensi Karsch 2e3e 
NMR structure of DEF-BBB, a mutant of anopheles defensin DEF-AAA 2e3f 
NMR structure of DEF-BAT, a mutant of anopheles defensin DEF-AAA 2e3g 
NMR structure of DEF-DAA, a mutant of anopheles defensin DEF-AAA 2gl1 
NMR solution structure of Vigna radiata Defensin 2 (VrD2) 2i61 
Depressant anti-insect neurotoxin, LqhIT2 from Leiurus quinquestriatus hebraeus 2kbh 
solution structure of BmKalphaTx11 (major conformation) 2kbj 
solution structure of BmKalphaTx11 (minor conformation) 2kbk 
Solution Structure of BmK-M10 2kja 
Chemical shift assignments, constraints, and coordinates for CN5 scorpion toxin 2kpy 
Solution Structure of the major allergen of Artemisia vulgaris (Art v 1) 2ksk 
Solution Structure of Sugarcane defensin 5 2li7 
Solution Structure of CssII 2lj7 
3D solution structure of plant defensin Lc-def 2ljm 
Solution Structure of CssII 2lkb 
Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels 2lld 
The Insect Defensin Lucifensin from Lucilia sericata 2ln4 
Insight into the antimicrobial activities based on the Structure-activity relationships of coprisin isolated from the Dung Beetle, Copris tripartitus 2lr3 
Solution structure of the anti-fungal defensin DEF4 (MTR_8g070770) from Medicago truncatula (barrel clover) 2m8b 
Solution structure of AhPDF1 from Arabidopsis halleri 2mz0 
2MZ0 2n2q 
2N2Q 2n2r 
2N2R 2n69 
2N69 2ny8 
NMR structure of antibacterial defensin DEF-AAA from the insect anopheles gambiae 2ny9 
NMR structure of DEF-ABB, a mutant of anopheles defensin DEF-AAA 2nz3 
NMR structure of DEF-AcAA, a mutant of anopheles defensin DEF-AAA 2sn3 
STRUCTURE OF SCORPION TOXIN VARIANT-3 AT 1.2 ANGSTROMS RESOLUTION 2ybr 
Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann 2yc1 
Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann 2yeo 
A39L mutation of scorpion toxin lqh-alpha-it 3psm 
.98A crystal structure of a dimeric plant defensin SPE10 4aaz 
X-ray structure of Nicotiana alata Defensin 1 NaD1 4ab0 
X-ray crystal structure of Nicotiana alata defensin NaD1 4aei 
Crystal structure of the AaHII-Fab4C1 complex 4cqk 
Crystal structure of ligand-bound NaD1 4hhf 
Crystal Structure of chemically synthesized scorpion alpha-toxin OD1 4kyp 
Beta-Scorpion Toxin folded in the periplasm of E.coli 4uj0 
4UJ0 4v1d 
4V1D 5cy0 
5CY0 5kk4 
5KK4 - Links (links to other resources describing this domain)
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INTERPRO IPR003614