Ku78Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen
|SMART accession number:||SM00559|
|Description:||This is a single stranded DNA- and ATP-depedent helicase that has a role in chromosome translocation. This is a domain of unknown function C-terminal to its von Willebrand factor A domain, that also occurs in bacterial hypothetical proteins.|
|Interpro abstract (IPR006164):|
The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 and Ku80 proteins that form a DNA binding heterodimer [(PUBMED:11493912)].
|GO process:||double-strand break repair via nonhomologous end joining (GO:0006303)|
|GO function:||DNA binding (GO:0003677)|
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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