SMART: LRR domain annotation

LRR Leucine-rich repeats, outliers

SMART accession number:	SM00370
Description:
Family alignment:	View or

There are 118887 LRR domains in 20085 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with LRR domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: signalling, translation
Binding / catalysis: Protein-binding
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Radauer C, Lackner P, Breiteneder H
- The Bet v 1 fold: an ancient, versatile scaffold for binding of large,hydrophobic ligands.
- BMC Evol Biol. 2008; 8: 286-286
- Display abstract
- BACKGROUND: The major birch pollen allergen, Bet v 1, is a member of theubiquitous PR-10 family of plant pathogenesis-related proteins. In recentyears, a number of diverse plant proteins with low sequence similarity toBet v 1 was identified. In addition, determination of the Bet v 1structure revealed the existence of a large superfamily of structurallyrelated proteins. In this study, we aimed to identify and classify all Betv 1-related structures from the Protein Data Bank and all Bet v 1-relatedsequences from the Uniprot database. RESULTS: Structural comparisons ofrepresentative members of already known protein families structurallyrelated to Bet v 1 with all entries of the Protein Data Bank yielded 47structures with non-identical sequences. They were classified into elevenfamilies, five of which were newly identified and not included in theStructural Classification of Proteins database release 1.71. The taxonomicdistribution of these families extracted from the Pfam protein familydatabase showed that members of the polyketide cyclase family and theactivator of Hsp90 ATPase homologue 1 family were distributed among allthree superkingdoms, while members of some bacterial families wereconfined to a small number of species. Comparison of ligand bindingactivities of Bet v 1-like superfamily members revealed that theirfunctions were related to binding and metabolism of large, hydrophobiccompounds such as lipids, hormones, and antibiotics. Phylogeneticrelationships within the Bet v 1 family, defined as the group of proteinswith significant sequence similarity to Bet v 1, were determined byaligning 264 Bet v 1-related sequences. A distance-based phylogenetic treeyielded a classification into 11 subfamilies, nine exclusively containingplant sequences and two subfamilies of bacterial proteins. Plant sequencesincluded the pathogenesis-related proteins 10, the major latexproteins/ripening-related proteins subfamily, and polyketide cyclase-likesequences. CONCLUSION: The ubiquitous distribution of Bet v 1-relatedproteins among all superkingdoms suggests that a Bet v 1-like protein wasalready present in the last universal common ancestor. During evolution,this protein diversified into numerous families with low sequencesimilarity but with a common fold that succeeded as a versatile scaffoldfor binding of bulky ligands.
- Kajava AV
- Structural diversity of leucine-rich repeat proteins.
- J Mol Biol. 1998; 277: 519-27
- Display abstract
- The superfamily of leucine-rich repeat proteins can be subdivided into at least six subfamilies, characterised by different lengths and consensus sequences of the repeats. It was proposed that the repeats from different subfamilies retain a similar superhelical fold, but differ in the three-dimensional structures of individual repeats. The sequence-structure relationship of three new subfamilies was examined by molecular modelling. I provide structural models for the repeats of all subfamilies. The models enable me to explain residue conservations within each subfamily. Furthermore, the difference in the packing explains why the repeats from different subfamilies never occur simultaneously in the same protein. Finally, these studies suggest different evolutionary origins for the different subfamilies. The approach used for the prediction of the leucine-rich repeat protein structures can be applied to other proteins containing internal repeats of about 20 to 30 residue in length.
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of LRR domains in PDB

PDB code	Main view	Title
1a4y		Ribonuclease inhibitor-angiogenin complex
1d0b		Internalin b leucine rich repeat domain
1dce		Crystal structure of rab geranylgeranyltransferase from rat brain
1dfj		Ribonuclease inhibitor complexed with ribonuclease a
1ds9		Solution structure of chlamydomonas outer arm dynein light chain 1
1fqv		Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
1fs2		Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
1g9u		Crystal structure of yopm-leucine rich effector protein from yersinia pestis
1gwb		Structure of glycoprotein 1b
1h6t		Internalin b: crystal structure of fused n-terminal domains.
1h6u		Internalin h: crystal structure of fused n-terminal domains.
1jl5		Novel molecular architecture of yopm-a leucine-rich effector protein from yersinia pestis
1k5d		Crystal structure of ran-gppnhp-ranbp1-rangap complex
1k5g		Crystal structure of ran-gdp-alfx-ranbp1-rangap complex
1ltx		Structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
1m0z		Crystal structure of the von willebrand factor binding domain of glycoprotein ib alpha
1m10		Crystal structure of the complex of glycoprotein ib alpha and the von willebrand factor a1 domain
1m9l		Relaxation-based refined structure of chlamydomonas outer arm dynein light chain 1
1m9s		Crystal structure of internalin b (inlb), a listeria monocytogenes virulence protein containing sh3-like domains.
1o6s		Internalin (listeria monocytogenes) / e-cadherin (human) recognition complex
1o6t		Internalin (inla,listeria monocytogenes) - functional domain,uncomplexed
1o6v		Internalin (inla,listeria monocytogenes) - functional domain, uncomplexed
1ook		Crystal structure of the complex of platelet receptor gpib- alpha and human alpha-thrombin
1otm		Calcium-binding mutant of the internalin b lrr domain
1otn		Calcium-binding mutant of the internalin b lrr domain
1oto		Calcium-binding mutant of the internalin b lrr domain
1ozn		1.5a crystal structure of the nogo receptor ligand binding domain reveals a convergent recognition scaffold mediating inhibition of myelination
1p8t		Crystal structure of nogo-66 receptor
1p8v		Crystal structure of the complex of platelet receptor gpib- alpha and alpha-thrombin at 2.6a
1p9a		Crystal structure of n-terminal domain of human platelet receptor glycoprotein ib-alpha at 1.7 angstrom resolution
1qyy		Crystal structure of n-terminal domain of human platelet receptor glycoprotein ib-alpha at 2.8 angstrom resolution
1sq0		Crystal structure of the complex of the wild-type von willebrand factor a1 domain and glycoprotein ib alpha at 2.6 angstrom resolution
1u0n		The ternary von willebrand factor a1-glycoprotein ibalpha- botrocetin complex
1w8a		Third lrr domain of drosophila slit
1xcd		Dimeric bovine tissue-extracted decorin, crystal form 1
1xec		Dimeric bovine tissue-extracted decorin, crystal form 2
1xeu		Crystal structure of internalin c from listeria monocytogenes
1xku		Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan
1yrg		The crystal structure of rna1p: a new fold for a gtpase- activating protein
1z7x		X-ray structure of human ribonuclease inhibitor complexed with ribonuclease i
1ziw		Human toll-like receptor 3 extracellular domain structure
2a0z		The molecular structure of toll-like receptor 3 ligand binding domain
2ass		Crystal structure of the skp1-skp2-cks1 complex
2ast		Crystal structure of skp1-skp2-cks1 in complex with a p27 peptide
2bex		Crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
2bnh		Porcine ribonuclease inhibitor
2ca6		Miras structure determination from hemihedrally twinned crystals
2ft3		Crystal structure of the biglycan dimer core protein
2id5		Crystal structure of the lingo-1 ectodomain
2o6q		Structural diversity of the hagfish variable lymphocyte receptors a29
2o6r		Structural diversity of the hagfish variable lymphocyte receptors b61
2o6s		Structural diversity of the hagfish variable lymphocyte receptors b59
2omt		Crystal structure of inla g194s+s/hec1 complex
2omu		Crystal structure of inla g194s+s y369s/hec1 complex
2omv		Crystal structure of inla s192n y369s/hec1 complex
2omw		Crystal structure of inla s192n y369s/mec1 complex
2omx		Crystal structure of inla s192n g194s+s/hec1 complex
2omy		Crystal structure of inla s192n/hec1 complex
2omz		Crystal structure of inla y369a/hec1 complex
2p1m		Tir1-ask1 complex structure
2p1n		Mechanism of auxin perception by the tir1 ubiqutin ligase
2p1o		Mechanism of auxin perception by the tir1 ubiquitin ligase
2p1p		Mechanism of auxin perception by the tir1 ubiquitin ligase
2p1q		Mechanism of auxin perception by the tir1 ubiquitin ligase
2q4g		Ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
2r9u		Crystal structure of lamprey variable lymphocyte receptor ectodomain
2uzx		Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i
2uzy		Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: low resolution, crystal form ii
2v70		Third lrr domain of human slit2
2v9s		Second lrr domain of human slit2
2v9t		Complex between the second lrr domain of slit2 and the first ig domain from robo1
2wfh		The human slit 2 dimerization domain d4
2wqu		Internalin domain of listeria monocytogenes inlb: triclinic crystal form
2wqv		Internalin domain of listeria monocytogenes inlb: rhombohedral crystal form
2wqw		Double-disulfide cross-linked crystal dimer of the listeria monocytogenes inlb internalin domain
2wqx		Inlb321_4r: s199r, d200r, g206r, a227r, c242a mutant of the listeria monocytogenes inlb internalin domain
2z62		Crystal structure of the tv3 hybrid of human tlr4 and hagfish vlrb.61
2z63		Crystal structure of the tv8 hybrid of human tlr4 and hagfish vlrb.61
2z64		Crystal structure of mouse tlr4 and mouse md-2 complex
2z65		Crystal structure of the human tlr4 tv3 hybrid-md-2- eritoran complex
2z66		Crystal structure of the vt3 hybrid of human tlr4 and hagfish vlrb.61
2z7x		Crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide
2z80		Crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide
2z81		Crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide
2z82		Crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide
3a79		Crystal structure of tlr2-tlr6-pam2csk4 complex
3a7b		Crystal structure of tlr2-streptococcus pneumoniae lipoteichoic acid complex
3a7c		Crystal structure of tlr2-pe-dtpa complex
3c6n		Small molecule agonists and antagonists of f-box protein- substrate interactions in auxin perception and signaling
3c6o		Small molecule agonists and antagonists of f-box protein- substrate interactions in auxin perception and signaling
3c6p		Small molecule agonists and antagonists of f-box protein- substrate interactions in auxin perception and signaling
3cig		Crystal structure of mouse tlr3 ectodomain
3ciy		Mouse toll-like receptor 3 ectodomain complexed with double- stranded rna
3cvr		Crystal structure of the full length ipah3
3e6j		Crystal structure of variable lymphocyte receptor (vlr) rbc36 in complex with h-trisaccharide
3fxi		Crystal structure of the human tlr4-human md-2-e.coli lps ra complex
3g06		The salmonella virulence effector ssph2 functions as a novel e3 ligase
3g39		Structure of a lamprey variable lymphocyte receptor
3g3a		Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen
3g3b		Structure of a lamprey variable lymphocyte receptor mutant in complex with a protein antigen