LRRCTLeucine rich repeat C-terminal domain
|SMART accession number:||SM00082|
|Interpro abstract (IPR000483):|
Leucine-rich repeats (LRR, see IPR001611) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [(PUBMED:14747988)]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [(PUBMED:11751054)]. Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response.
LRRs are often flanked by cysteine-rich domains: an N-terminal LRR domain (IPR000372) and a C-terminal LRR domain. This entry represents the C-terminal LRR domain.
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- Evolution (species in which this domain is found)
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- Disease (disease genes where sequence variants are found in this domain)
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