LRRCTLeucine rich repeat C-terminal domain
|SMART accession number:||SM00082|
|Interpro abstract (IPR000483):|
Leucine-rich repeats (LRR, see IPR001611) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [(PUBMED:14747988)]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [(PUBMED:11751054)]. Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response.
LRRs are often flanked by cysteine-rich domains: an N-terminal LRR domain (IPR000372) and a C-terminal LRR domain. This entry represents the C-terminal LRR domain.
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- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing LRRCT domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with LRRCT domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing LRRCT domain in the selected taxonomic class.
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Kobe B, Deisenhofer J
- A structural basis of the interactions between leucine-rich repeats and protein ligands.
- Nature. 1995; 374: 183-6
- Display abstract
The leucine-rich repeat is a recently characterized structural motif used in molecular recognition processes as diverse as signal transduction, cell adhesion, cell development, DNA repair and RNA processing. We present here the crystal structure at 2.5 A resolution of the complex between ribonuclease A and ribonuclease inhibitor, a protein built entirely of leucine-rich repeats. The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel beta-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs. The structure can serve as a model for the interactions of other proteins containing leucine-rich repeats with their ligands.
- Kobe B, Deisenhofer J
- The leucine-rich repeat: a versatile binding motif.
- Trends Biochem Sci. 1994; 19: 415-21
- Display abstract
Leucine-rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. All proteins containing these repeats are thought to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor protein has revealed that leucine-rich repeats correspond to beta-alpha structural units. These units are arranged so that they form a parallel beta-sheet with one surface exposed to solvent, so that the protein acquires an unusual, nonglobular shape. These two features may be responsible for the protein-binding functions of proteins containing leucine-rich repeats.
- Disease (disease genes where sequence variants are found in this domain)
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the LRRCT domain.
Protein Disease Platelet glycoprotein Ib alpha chain (P07359) (SMART) OMIM:231200: Bernard-Soulier syndrome
- Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath
% proteins involved KEGG pathway ID Description 36.42 map04620 Toll-like receptor signaling pathway 16.18 map04512 ECM-receptor interaction 13.29 map04360 Axon guidance 12.14 map04640 Hematopoietic cell lineage 6.94 map04010 MAPK signaling pathway 4.05 map04510 Focal adhesion 2.89 map05216 Thyroid cancer 2.89 map04210 Apoptosis 1.73 map00680 Methane metabolism 1.73 map00940 Phenylpropanoid biosynthesis 1.73 map00360 Phenylalanine metabolism
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LRRCT domain which could be assigned to a KEGG orthologous group, and not all proteins containing LRRCT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of LRRCT domains in PDB
PDB code Main view Title 1gwb structure of glycoprotein 1b 1m0z Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha 1m10 Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain 1ook Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin 1ozn 1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination 1p8t Crystal structure of Nogo-66 Receptor 1p8v CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A 1p9a Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 1.7 Angstrom Resolution 1qyy Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution 1sq0 Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution 1u0n The ternary von Willebrand Factor A1-glycoprotein Ibalpha-botrocetin complex 1w8a Third LRR domain of Drosophila Slit 1ziw Human Toll-like Receptor 3 extracellular domain structure 2a0z The molecular structure of toll-like receptor 3 ligand binding domain 2id5 Crystal Structure of the Lingo-1 Ectodomain 2ifg Structure of the extracellular segment of human TRKA in complex with nerve growth factor 2o6r Structural diversity of the hagfish Variable Lymphocyte Receptors B61 2o6s Structural diversity of the hagfish Variable Lymphocyte Receptors B59 2r9u Crystal Structure of Lamprey Variable Lymphocyte Receptor 2913 Ectodomain 2v70 Third LRR domain of human Slit2 2v9s Second LRR domain of human Slit2 2v9t Complex between the second LRR domain of Slit2 and The first Ig domain from Robo1 2wfh The Human Slit 2 Dimerization Domain D4 2xot Crystal structure of neuronal leucine rich repeat protein AMIGO-1 2z62 Crystal structure of the TV3 hybrid of human TLR4 and hagfish VLRB.61 2z63 Crystal structure of the TV8 hybrid of human TLR4 and hagfish VLRB.61 2z65 Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex 2z66 Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61 2z7x Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide 2z80 Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide 2z81 Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide 2z82 Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide 3a79 Crystal structure of TLR2-TLR6-Pam2CSK4 complex 3a7b Crystal structure of TLR2-Streptococcus Pneumoniae lipoteichoic acid complex 3a7c Crystal structure of TLR2-PE-DTPA complex 3b2d Crystal structure of human RP105/MD-1 complex 3cig Crystal structure of mouse TLR3 ectodomain 3ciy Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA 3e6j Crystal Structure of Variable Lymphocyte Receptor (VLR) RBC36 in Complex with H-trisaccharide 3fxi Crystal structure of the human TLR4-human MD-2-E.coli LPS Ra complex 3j0a Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction 3kj4 Structure of rat Nogo receptor bound to 1D9 antagonist antibody 3p72 structure of platelet Glycoprotein 1b alpha with a bound peptide inhibitor 3pmh Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites 3rez glycoprotein GPIb variant 3rfe Crystal structure of glycoprotein GPIb ectodomain 3rfs Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering 3rg1 Crystal structure of the RP105/MD-1 complex 3t6q Crystal structure of mouse RP105/MD-1 complex 3ul7 Crystal structure of the TV3 mutant F63W 3ul8 Crystal structure of the TV3 mutant V134L 3ul9 structure of the TV3 mutant M41E 3ula Crystal structure of the TV3 mutant F63W-MD-2-Eritoran complex 3ulu Structure of quaternary complex of human TLR3ecd with three Fabs (Form1) 3ulv Structure of quaternary complex of human TLR3ecd with three Fabs (Form2) 3v44 Crystal structure of the N-terminal fragment of zebrafish TLR5 3v47 Crystal structure of the N-tetminal fragment of zebrafish TLR5 in complex with Salmonella flagellin 3vq1 Crystal structure of mouse TLR4/MD-2/lipid IVa complex 3vq2 Crystal structure of mouse TLR4/MD-2/LPS complex 3w3g Crystal structure of human TLR8 (unliganded form) 3w3j Crystal structure of human TLR8 in complex with CL097 3w3k Crystal structure of human TLR8 in complex with CL075 3w3l Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 1 3w3m Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2 3w3n Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3 3wn4 Crystal structure of human TLR8 in complex with DS-877 3zyi NetrinG2 in complex with NGL2 3zyj NetrinG1 in complex with NGL1 3zyn Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3 3zyo Crystal structure of the N-terminal leucine rich repeats and immunoglobulin domain of netrin-G ligand-3 4arn Crystal structure of the N-terminal domain of Drosophila Toll receptor 4arr Crystal structure of the N-terminal domain of Drosophila Toll receptor with the magic triangle I3C 4bv4 Structure and allostery in Toll-Spatzle recognition 4c2a Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha 4c2b Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha 4cnc Crystal structure of human 5T4 (Wnt-activated inhibitory factor 1, Trophoblast glycoprotein) 4cnm Crystal structure of human 5T4 (Wnt-activated inhibitory factor 1, Trophoblast glycoprotein) 4g8a Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS 4j4l Modular evolution and design of the protein binding interface 4lxr Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity 4lxs Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity (glycosylated form) 4oqt LINGO-1/Li81 Fab complex 4p8s Crystal structure of Nogo-receptor-2 4p91 Crystal structure of the nogo-receptor-2 (27-330)
- Links (links to other resources describing this domain)