Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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LYZ2 Lysozyme subfamily 2

SMART accession number:	SM00047
Description:	Eubacterial enzymes distantly related to eukaryotic lysozymes.
Interpro abstract (IPR013338):	This domain is found in many different proteins including mannosyl-glycoprotein endo-beta-N-acetylglucosamidase (EC 3.2.1.96).It is also found in flagellar protein J (P75942), which has been shown to hydrolyse peptidoglycan [(PUBMED:10049388)].
GO process:	cellular cell wall macromolecule metabolic process (GO:0010382)
GO function:	hydrolase activity (GO:0016787)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 499 LYZ2 domains in 499 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a LYZ2 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with LYZ2 domain is also avaliable.

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• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 30.00 map00511 N-Glycan degradation 30.00 map01032 Glycan structures - degradation 20.00 map02040 Flagellar assembly 6.67 map00550 Peptidoglycan biosynthesis 3.33 map00604 Glycosphingolipid biosynthesis - ganglioseries 3.33 map00531 Glycosaminoglycan degradation 3.33 map00530 Aminosugars metabolism 3.33 map00603 Glycosphingolipid biosynthesis - globoseries This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LYZ2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing LYZ2 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of LYZ2 domains in PDB

  PDB code	Main view	Title
  2zyc		Crystal structure of peptidoglycan hydrolase from sphingomonas sp. a1
  3fi7		Crystal structure of the autolysin auto (lmo1076) from listeria monocytogenes, catalytic domain

• Links (links to other resources describing this domain)

• INTERPRO	IPR013338

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