This LamG-like jellyroll fold domain is found in the metalloproteinase Pappalysin-1 [ (PUBMED:17314100) ] and Usherin [ (PUBMED:17360538) ]. Its function is unknown.
Family alignment:
There are 2130 LamGL domains in 997 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing LamGL domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with LamGL domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing LamGL domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins.
J Mol Biol. 1998; 275: 725-30
Display abstract
Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. The conserved patterns correspond mainly to hydrophobic core residues located in central beta strands of the known three-dimensional structures of two pentraxins, the human C-reactive protein and the serum amyloid P-component. Thus, we predict a similar jellyroll fold for all members of this superfamily. In addition, the conservation of two exposed aspartate residues in the majority of superfamily members suggests hitherto unrecognised functional sites.
Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LamGL domain which could be assigned to a KEGG orthologous group, and not all proteins containing LamGL domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
