Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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M16C_associated Peptidase M16C associated

SMART accession number:	SM01264
Description:	This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease (PFAM PF05193).
Interpro abstract (IPR013578):	This domain appears in eukaryotes as well as bacteria and tends to be found near the C terminus of metalloproteases and related sequences belonging to MEROPS peptidase family M16 (subfamily M16C, clan ME), PreP subfamily. PREP is an ATP-independent protease that degrades both mitochondrial and chloroplastic transit peptides after their cleavage. It also degrades other unstructured peptides [ (PUBMED:12138166) ].
GO process:	proteolysis (GO:0006508)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 4384 M16C_associated domains in 4384 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing M16C_associated domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with M16C_associated domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing M16C_associated domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of M16C_associated domains in PDB

  PDB code	Main view	Title
  2fge		Crystal structure of presequence protease PreP from Arabidopsis thaliana
  3s5h		Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum
  3s5i		Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum
  3s5k		Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum
  3s5m		Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum
  4l3t		Crystal Structure of Substrate-free Human Presequence Protease
  4nge		Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)
  4rpu		4RPU

• Links (links to other resources describing this domain)

• PFAM	M16C_assoc
  INTERPRO	IPR013578

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