MAGE

Melanoma-associated antigen
MAGE
SMART accession number:SM01373
Description: The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex (PMID:15601840, 15331764). Nse3 has been demonstrated to be important for (PMID:15331764).
Family alignment:
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There are 2791 MAGE domains in 2660 proteins in SMART's nrdb database.

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