• Links (links to other resources describing this domain)
  • MIT

    Microtubule Interacting and Trafficking molecule domain
    SMART accession number:SM00745
    Description: -
    Interpro abstract (IPR007330):

    The MIT domain forms an asymmetric three-helix bundle. It is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.

    A 'variant' MIT domain has been described at the N-terminal region of a related AAA-ATPase, mammalian katanin p60 [(PUBMED:20339000)].

    Family alignment:
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    There are 1611 MIT domains in 1401 proteins in SMART's nrdb database.

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