MR_MLE

Mandelate racemase / muconate lactonizing enzyme, C-terminal domain
MR_MLE
SMART accession number:SM00922
Description: Mandelate racemase (MR) and muconate lactonizing enzyme (MLE) are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures (PUBMED:2215699), (PUBMED:8256284). This entry represents the C-terminal region of these proteins.
Interpro abstract (IPR013342):

Mandelate racemase EC 5.1.2.2 (MR) and muconate lactonising enzyme EC 5.5.1.1 (MLE) are two bacterial enzymes involved in aromatic acid catabolism. They catalyse mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures [(PUBMED:2215699), (PUBMED:8256284)]. A number of other proteins also seem to be evolutionary related to these two enzymes. These include, various plasmid-encoded chloromuconate cycloisomerases EC 5.5.1.7, Escherichia coli protein rspA [(PUBMED:7545940)], E. coli bifunctional DGOA protein, E. coli hypothetical proteins ycjG, yfaW and yidU and a hypothetical protein from Streptomyces ambofaciens [(PUBMED:8277241)].

This entry represents the C-terminal region of these proteins.

Family alignment:
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There are 13860 MR_MLE domains in 13860 proteins in SMART's nrdb database.

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