Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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Molybdop_Fe4S4 Molybdopterin oxidoreductase Fe4S4 domain

SMART accession number:	SM00926
Description:	The molybdopterin oxidoreductase Fe4S4 domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain.
Interpro abstract (IPR006963):	The molybdopterin oxidoreductase Fe4S4 domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [(PUBMED:9036855)].
GO process:	oxidation-reduction process (GO:0055114)
GO function:	oxidoreductase activity (GO:0016491)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 4939 Molybdop_Fe4S4 domains in 4939 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a Molybdop_Fe4S4 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with Molybdop_Fe4S4 domain is also avaliable.

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• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of Molybdop_Fe4S4 domains in PDB

  PDB code	Main view	Title
  1aa6		Reduced form of formate dehydrogenase h from e. coli
  1fdi		Oxidized form of formate dehydrogenase h from e. coli complexed with the inhibitor nitrite
  1fdo		Oxidized form of formate dehydrogenase h from e. coli
  1h0h		Tungsten containing formate dehydrogenase from desulfovibrio gigas
  1kqf		Formate dehydrogenase n from e. coli
  1kqg		Formate dehydrogenase n from e. coli
  1ogy		Crystal structure of the heterodimeric nitrate reductase from rhodobacter sphaeroides
  1q16		Crystal structure of nitrate reductase a, narghi, from escherichia coli
  1r27		Crystal structure of nargh complex
  1siw		Crystal structure of the apomolybdo-narghi
  1y4z		The crystal structure of nitrate reductase a, narghi, in complex with the q-site inhibitor pentachlorophenol
  1y5i		The crystal structure of the narghi mutant nari-k86a
  1y5l		The crystal structure of the narghi mutant nari-h66y
  1y5n		The crystal structure of the narghi mutant nari-k86a in complex with pentachlorophenol
  2fug		Crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus
  2iv2		Reinterpretation of reduced form of formate dehydrogenase h from e. coli
  2jim		A new catalytic mechanism of periplasmic nitrate reductase from desulfovibrio desulfuricans atcc 27774 from crystallographic and epr data and based on detailed analysis of the sixth ligand
  2jio		A new catalytic mechanism of periplasmic nitrate reductase from desulfovibrio desulfuricans atcc 27774 from crystallographic and epr data and based on detailed analysis of the sixth ligand
  2jip		A new catalytic mechanism of periplasmic nitrate reductase from desulfovibrio desulfuricans atcc 27774 from crystallographic and epr data and based on detailed analysis of the sixth ligand
  2jiq		A new catalytic mechanism of periplasmic nitrate reductase from desulfovibrio desulfuricans atcc 27774 from crystallographic and epr data and based on detailed analysis of the sixth ligand
  2jir		A new catalytic mechanism of periplasmic nitrate reductase from desulfovibrio desulfuricans atcc 27774 from crystallographic and epr data and based on detailed analysis of the sixth ligand
  2nap		Dissimilatory nitrate reductase (nap) from desulfovibrio desulfuricans
  2nya		Crystal structure of the periplasmic nitrate reductase (nap) from escherichia coli
  2v3v		A new catalytic mechanism of periplasmic nitrate reductase from desulfovibrio desulfuricans atcc 27774 from crystallographic and epr data and based on detailed analysis of the sixth ligand
  2v45		A new catalytic mechanism of periplasmic nitrate reductase from desulfovibrio desulfuricans atcc 27774 from crystallographic and epr data and based on detailed analysis of the sixth ligand
  2vpw		Polysulfide reductase with bound menaquinone
  2vpx		Polysulfide reductase with bound quinone (uq1)
  2vpy		Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (pcp)
  2vpz		Polysulfide reductase native structure
  3i9v		Crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus, oxidized, 2 mol/asu
  3iam		Crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus, reduced, 2 mol/asu, with bound nadh
  3ias		Crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus, oxidized, 4 mol/asu, re-refined to 3.15 angstrom resolution

• Links (links to other resources describing this domain)

• PFAM	Molybdop_Fe4S4
  INTERPRO	IPR006963

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