Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Molybdop_Fe4S4 Molybdopterin oxidoreductase Fe4S4 domain

SMART accession number:	SM00926
Description:	The molybdopterin oxidoreductase Fe4S4 domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain.
Interpro abstract (IPR006963):	The molybdopterin oxidoreductase 4Fe-4S domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [ (PUBMED:9036855) ]. The following proteins contain this domain and belong to the molybdenium (Mo) or tungsten (W) containing enzyme family, the Mo/W bis-MGD (molybdopterin-guanine-dinucleotide) oxydoreductases [ (PUBMED:2015248) (PUBMED:3062312) (PUBMED:8125918) ]: Escherichia coli respiratory nitrate reductase ( EC 1.7.99.4 ). Escherichia coli anaerobic dimethyl sulfoxide reductase (DMSO reductase). Escherichia coli biotin sulfoxide reductases (genes bisC and bisZ). Methanobacterium formicicum formate dehydrogenase ( EC 1.2.1.2 ). Escherichia coli formate dehydrogenases -H (gene fdhF), -N (gene fdnG) and -O (gene fdoG). Wolinella succinogenes polysulfide reductase chain. Salmonella typhimurium thiosulfate reductase (gene phsA). Escherichia coli trimethylamine-N-oxide reductase ( EC 1.6.6.9 ) (gene torA) [ (PUBMED:8022286) ]. Nitrate reductase ( EC 1.7.99.4 ) from Klebsiella pneumoniae (gene nasA), Alcaligenes eutrophus, Escherichia coli, Rhodobacter sphaeroides, Thiosphaera pantotropha (gene napA), and Synechococcus PCC 7942 (gene narB).
GO process:	oxidation-reduction process (GO:0055114)
GO function:	oxidoreductase activity (GO:0016491)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 56452 Molybdop_Fe4S4 domains in 56452 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Molybdop_Fe4S4 domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Molybdop_Fe4S4 domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Molybdop_Fe4S4 domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of Molybdop_Fe4S4 domains in PDB

  PDB code	Main view	Title
  1aa6		REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI
  1fdi		OXIDIZED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI COMPLEXED WITH THE INHIBITOR NITRITE
  1fdo		OXIDIZED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI
  1h0h		Tungsten containing Formate Dehydrogenase from Desulfovibrio Gigas
  1kqf		FORMATE DEHYDROGENASE N FROM E. COLI
  1kqg		FORMATE DEHYDROGENASE N FROM E. COLI
  1ogy		Crystal structure of the heterodimeric nitrate reductase from Rhodobacter sphaeroides
  1q16		Crystal structure of Nitrate Reductase A, NarGHI, from Escherichia coli
  1r27		Crystal Structure of NarGH complex
  1siw		Crystal structure of the apomolybdo-NarGHI
  1y4z		The crystal structure of Nitrate Reductase A, NarGHI, in complex with the Q-site inhibitor pentachlorophenol
  1y5i		The crystal structure of the NarGHI mutant NarI-K86A
  1y5l		The crystal structure of the NarGHI mutant NarI-H66Y
  1y5n		The crystal structure of the NarGHI mutant NarI-K86A in complex with pentachlorophenol
  2fug		Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus
  2iv2		Reinterpretation of reduced form of formate dehydrogenase H from E. coli
  2jim		A New Catalytic Mechanism of Periplasmic Nitrate Reductase from Desulfovibrio desulfuricans ATCC 27774 from Crystallographic and EPR Data and based on detailed analysis of the sixth ligand
  2jio		A New Catalytic Mechanism of Periplasmic Nitrate Reductase from Desulfovibrio desulfuricans ATCC 27774 from Crystallographic and EPR Data and based on detailed analysis of the sixth ligand
  2jip		A New Catalytic Mechanism of Periplasmic Nitrate Reductase from Desulfovibrio desulfuricans ATCC 27774 from Crystallographic and EPR Data and based on detailed analysis of the sixth ligand
  2jiq		A New Catalytic Mechanism of Periplasmic Nitrate Reductase from Desulfovibrio desulfuricans ATCC 27774 from Crystallographic and EPR Data and based on detailed analysis of the sixth ligand
  2jir		A New Catalytic Mechanism of Periplasmic Nitrate Reductase from Desulfovibrio desulfuricans ATCC 27774 from Crystallographic and EPR Data and based on detailed analysis of the sixth ligand
  2nap		DISSIMILATORY NITRATE REDUCTASE (NAP) FROM DESULFOVIBRIO DESULFURICANS
  2nya		Crystal structure of the periplasmic nitrate reductase (NAP) from Escherichia coli
  2v3v		A New Catalytic Mechanism of Periplasmic Nitrate Reductase from Desulfovibrio desulfuricans ATCC 27774 from Crystallographic and EPR Data and based on detailed analysis of the sixth ligand
  2v45		A New Catalytic Mechanism of Periplasmic Nitrate Reductase from Desulfovibrio desulfuricans ATCC 27774 from Crystallographic and EPR Data and based on detailed analysis of the sixth ligand
  2vpw		Polysulfide reductase with bound menaquinone
  2vpx		Polysulfide reductase with bound quinone (UQ1)
  2vpy		Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (PCP)
  2vpz		Polysulfide reductase native structure
  2ybb		Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876)
  3egw		The crystal structure of the NarGHI mutant NarH - C16A
  3i9v		Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU
  3iam		Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH
  3ias		Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution
  3ir5		Crystal structure of NarGHI mutant NarG-H49C
  3ir6		Crystal structure of NarGHI mutant NarG-H49S
  3ir7		Crystal structure of NarGHI mutant NarG-R94S
  3m9s		Crystal structure of respiratory complex I from Thermus thermophilus
  3ml1		Crystal Structure of the Periplasmic Nitrate Reductase from Cupriavidus necator
  3o5a		Crystal Structure of partially reduced Periplasmic Nitrate Reductase from Cupriavidus necator using Ionic Liquids
  4hea		Crystal structure of the entire respiratory complex I from Thermus thermophilus

• Links (links to other resources describing this domain)

• INTERPRO	IPR006963
  PFAM	Molybdop_Fe4S4

Send comments to Ivica Letunic