MterfMitochondrial termination factor repeats
|SMART accession number:||SM00733|
|Description:||Human mitochondrial termination factor is a DNA-binding protein that acts as a transcription termination factor. Six repeats occur in human mTERF, that also are present in numerous plant proteins.|
|Interpro abstract (IPR003690):|
This entry represents the mitochondrial transcription termination factors (MTERFs). In humans four MTERFs have been identified (MTERF1-4). MTERF1 was first identified as a factor responsible for terminating heavy strand transcription at a specific site at the leu-tRNA, thereby modulating the ratio of mitochondrial ribosomal RNA to mRNA [(PUBMED:2752429)]. Later, MTERF1 was found to stimulate transcriptional initiation [(PUBMED:19366610)] and appeared to be in the control of mitochondrial replication pausing [(PUBMED:17884915)]. From a structural study, it binds to dsDNA containing the termination sequence and unwinds the DNA molecule, promoting base eversion, which is critical for transcription termination [(PUBMED:20550934)].
|GO process:||regulation of transcription, DNA-templated (GO:0006355)|
|GO component:||mitochondrion (GO:0005739)|
|GO function:||double-stranded DNA binding (GO:0003690)|
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Literature (relevant references for this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)