Mterf

Mitochondrial termination factor repeats
Mterf
SMART accession number:SM00733
Description: Human mitochondrial termination factor is a DNA-binding protein that acts as a transcription termination factor. Six repeats occur in human mTERF, that also are present in numerous plant proteins.
Interpro abstract (IPR003690):

This entry represents the mitochondrial transcription termination factors (MTERFs). In humans four MTERFs have been identified (MTERF1-4). MTERF1 was first identified as a factor responsible for terminating heavy strand transcription at a specific site at the leu-tRNA, thereby modulating the ratio of mitochondrial ribosomal RNA to mRNA [(PUBMED:2752429)]. Later, MTERF1 was found to stimulate transcriptional initiation [(PUBMED:19366610)] and appeared to be in the control of mitochondrial replication pausing [(PUBMED:17884915)]. From a structural study, it binds to dsDNA containing the termination sequence and unwinds the DNA molecule, promoting base eversion, which is critical for transcription termination [(PUBMED:20550934)].

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO component:mitochondrion (GO:0005739)
GO function:double-stranded DNA binding (GO:0003690)
Family alignment:
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There are 9869 Mterf domains in 1788 proteins in SMART's nrdb database.

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