MterfMitochondrial termination factor repeats
|SMART accession number:||SM00733|
|Description:||Human mitochondrial termination factor is a DNA-binding protein that acts as a transcription termination factor. Six repeats occur in human mTERF, that also are present in numerous plant proteins.|
|Interpro abstract (IPR003690):|
This family currently contains one sequence of known function human mitochondrial transcription termination factor (mTERF), a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions [(PUBMED:9118945)]. The precursors contain a mitochondrial targeting sequence, and the mature mTERF exhibits three leucine zippers, of which one is bipartite, and two widely spaced basic domains. Both basic domains and the three leucine zipper motifs are necessary for DNA binding. The leucine zippers are not implicated in a dimerisation role as in other leucine zippers [(PUBMED:9118945)].
The rest of the family consists of hypothetical proteins none of which have any functional information.
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- Evolution (species in which this domain is found)
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