Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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NAT_PEP Natriuretic peptide

SMART accession number:	SM00183
Description:	Atrial natriuretic peptides are vertebrate hormones important in the overall control of cardiovascular homeostasis and sodium and water balance in general.
Interpro abstract (IPR000663):	Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of cardiovascular homeostatis, and sodium and water balance in general [(PUBMED:1652921), (PUBMED:2536732), ]. There are different NPs that vary in length but share a common core. All are processed from a single precursor. A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP) [(PUBMED:1828035)]; and green mamba natriuretic peptide (DNP) [(PUBMED:1352773)].
GO component:	extracellular region (GO:0005576)
GO function:	hormone activity (GO:0005179)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 245 NAT_PEP domains in 216 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a NAT_PEP domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with NAT_PEP domain is also avaliable.

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  Go to specific node: Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Structure (3D structures containing this domain)

• 3D Structures of NAT_PEP domains in PDB

  PDB code	Main view	Title
  1anp		Solution conformation of an atrial natriuretic peptide variant selective for the type-a receptor
  1jdp		Crystal structure of hormone/receptor complex
  1q01		Lebetin peptides, a new class of potent aggregation inhibitors
  1t34		Rotation mechanism for transmembrane signaling by the atrial natriuretic peptide receptor
  1yk0		Structure of natriuretic peptide receptor-c complexed with atrial natriuretic peptide
  1yk1		Structure of natriuretic peptide receptor-c complexed with brain natriuretic peptide

• Links (links to other resources describing this domain)

• BLOCKS	NATRIURETIC_PEPTIDE
  INTERPRO	IPR000663
  PROSITE	NATRIURETIC_PEPTIDE

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