Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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NDK

SMART accession number:	SM00562
Description:	These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.
Interpro abstract (IPR034907):	Nucleoside diphosphate kinases ( EC 2.7.4.6 ) (NDK) are enzymes required for the synthesis of nucleoside triphosphates (NTP) other than ATP. They provide NTPs for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerisation. NDK are proteins of 17 Kd that act via a ping-pong mechanism in which a histidine residue is phosphorylated, by transfer of the terminal phosphate group from ATP. In the presence of magnesium, the phosphoenzyme can transfer its phosphate group to any NDP, to produce an NTP. NDK isozymes have been sequenced from prokaryotic and eukaryotic sources. It has also been shown [ (PUBMED:2175255) ] that the Drosophila awd (abnormal wing discs) protein, is a microtubule-associated NDK. Mammalian NDK is also known as metastasis inhibition factor nm23. The sequence of NDK has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism [ (PUBMED:1851158) ]. The enzyme is a hexamer composed by identical subunits with a novel mononucleotide binding fold. Each subunit contains an alpha/beta domain with a four stranded, anti-parallel beta-sheet [ (PUBMED:556853) ]. This alpha/beta domain is also found at the C terminus of retinitis pigmentosa 2 protein (XRP2/RP2) [ (PUBMED:16472755) ]. XRP2, a GTPase-activating protein, is required for maintenance of rod and cone photoreceptor cells in the retina [ (PUBMED:26034134) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 22429 NDK domains in 21229 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing NDK domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with NDK domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing NDK domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Chakrabarty AM
  • Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signalling and polysaccharide synthesis.
  • Mol Microbiol. 1998; 28: 875-82
  • Display abstract

  • Nucleoside diphosphate kinase (Ndk) is an important enzyme that generates nucleoside triphosphates (NTPs) or their deoxy derivatives by terminal phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate or its deoxy derivative. As NTPs, particularly GTP, are important for cellular macromolecular synthesis and signalling mechanisms, Ndk plays an important role in bacterial growth, signal transduction and pathogenicity. Specific examples of the role of Ndk in regulating growth, NTP formation and cell surface polysaccharide synthesis in two respiratory tract pathogens, Pseudomonas aeruginosa and Mycobacterium tuberculosis, are discussed.

  • Postel EH
  • NM23-NDP kinase.
  • Int J Biochem Cell Biol. 1998; 30: 1291-5
  • Display abstract

  • NM23 belongs to a large family of structurally and functionally conserved proteins consisting of 4-6 identically folded subunits of approximately 16-20 kDa. These oligomeric proteins exhibit nucleoside diphosphate kinase (NDPK) activity that catalyzes nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. Many NM23 proteins bind DNA. In vivo, NM23-NDPKs regulate a diverse array of cellular events including growth and development. They are also implicated in the pathogenesis and metastasis of tumors. The mechanism whereby NM23 regulates gene expression is proposed to entail DNA-binding and subsequent alterations in promoter DNA structure. Accordingly, NM23 has the potential to become a useful reagent for gene manipulations.

  • Ogawa K et al.
  • Is outer arm dynein intermediate chain 1 multifunctional?
  • Mol Biol Cell. 1996; 7: 1895-907
  • Display abstract

  • The outer arm dynein of sea urchin sperm axoneme contains three intermediate chains (IC1, IC2, and IC3; M(r) 128,000, 98,000, and 74,000, respectively). IC2 and IC3 are members of the WD family; the WD motif is responsible for a protein-protein interaction. We describe here the molecular cloning of IC1. IC1 has a unique primary structure, the N-terminal part is homologous to the sequence of thioredoxin, the middle part consists of three repetitive sequences homologous to the sequence of nucleoside diphosphate kinase, and the C-terminal part contains a high proportion of negatively charged glutamic acid residues. Thus, IC1 is a novel dynein intermediate chain distinct from IC2 and IC3 and may be a multifunctional protein. The thioredoxin-related part of IC1 is more closely related to those of two redox-active Chlamydomonas light chains than thioredoxin. Antibodies were prepared against the N-terminal and middle domains of IC1 expressed as His-tagged proteins in bacteria. These antibodies cross-reacted with some dynein polypeptides (potential homologues of IC1) from distantly related species. We propose here that the three intermediate chains are the basic core units of sperm outer arm dynein because of their ubiquitous existence. The recombinant thioredoxin-related part of IC1 and outer arm dyneins from sea urchin and distantly related species were specifically bound to and eluted from a phenylarsine oxide affinity column with 2-mercaptoethanol, indicating that they contain vicinal dithiols competent to undergo reversible oxidation/reduction.

  • delaRosa A, Williams RL, Steeg PS
  • Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions.
  • Bioessays. 1995; 17: 53-62
  • Display abstract

  • The nm23 gene, a putative metastasis suppressor gene, was originally identified by its reduced expression in highly metastatic K-1735 murine melanoma cell lines, as compared to related, low metastatic melanoma cell lines. Transfection of nm23 cDNA has been reported to suppress malignant progression in Drosophila and mammalian cells. Highly conserved homologues of nm23 have been found in organisms ranging from the prokaryote Myxococcus xanthus to Drosophila, where the gene is involved in normal development and differentiation. The product of the nm23 gene exhibits a nucleoside diphosphate kinase activity, yet the nucleoside diphosphate kinase activity of Nm23 does not correlate with its apparent biological functions. We review recent cellular, genetic, biochemical and X-ray crystallographic data to formulate and evaluate hypotheses concerning the molecular mechanism of nm23 action.

  • Morera S et al.
  • Adenosine 5'-diphosphate binding and the active site of nucleoside diphosphate kinase.
  • Biochemistry. 1994; 33: 459-67
  • Display abstract

  • The X-ray structure of nucleoside diphosphate kinase (NDP kinase) from the slime mold Dictyostelium discoideum has been determined to 2.2-A resolution and refined to an R-factor of 0.19 with and without bound ADP-Mg2+. The nucleotide binds near His 122, a residue which becomes phosphorylated during the catalytic cycle. The mode of binding is different from that observed in other phosphokinases, and it involves no glycine-rich sequence. The adenine base makes only nonpolar contacts with the protein. It points outside, explaining the lack of specificity of NDP kinase toward the base. The ribose 2'- and 3'-hydroxyls and the pyrophosphate moiety are H-bonded to polar side chains. A Mg2+ ion bridges the alpha- to the beta-phosphate which approaches the imidazole group of His 122 from the N delta side. The geometry at the active site in the ADP-Mg2+ complex suggests a mechanism for catalysis whereby the gamma-phosphate of a nucleoside triphosphate can be transferred onto His 122 with a minimum of atomic motion.

  • Dumas C et al.
  • X-ray structure of nucleoside diphosphate kinase.
  • EMBO J. 1992; 11: 3203-8
  • Display abstract

  • The X-ray structure of a point mutant of nucleoside diphosphate kinase (NDP kinase) from Dictyostelium discoideum has been determined to 2.2 A resolution. The enzyme is a hexamer made of identical subunits with a novel mononucleotide binding fold. Each subunit contains an alpha/beta domain with a four stranded, antiparallel beta-sheet. The topology is different from adenylate kinase, but identical to the allosteric domain of Escherichia coli ATCase regulatory subunits, which bind mononucleotides at an equivalent position. Dimer contacts between NDP kinase subunits within the hexamer are similar to those in ATCase. Trimer contacts involve a large loop of polypeptide chain that bears the site of the Pro----Ser substitution in Killer of prune (K-pn) mutants of the highly homologous Drosophila enzyme. Properties of Drosophila NDP kinase, the product of the awd developmental gene, and of the human enzyme, the product of the nm23 genes in tumorigenesis, are discussed in view of the three-dimensional structure and of possible interactions of NDP kinase with other nucleotide binding proteins.

• Disease (disease genes where sequence variants are found in this domain)

• SwissProt sequences and OMIM curated human diseases associated with missense mutations within the NDK domain.

  Protein	Disease
  Nucleoside diphosphate kinase A (P15531) (SMART)	OMIM:156490: Neuroblastoma

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 50.00 map00240 Pyrimidine metabolism 50.00 map00230 Purine metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with NDK domain which could be assigned to a KEGG orthologous group, and not all proteins containing NDK domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of NDK domains in PDB

  PDB code	Main view	Title
  1b4s		STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE H122G MUTANT
  1b99		3'-FLUORO-URIDINE DIPHOSPHATE BINDING TO NUCLEOSIDE DIPHOSPHATE KINASE
  1be4		NUCLEOSIDE DIPHOSPHATE KINASE ISOFORM B FROM BOVINE RETINA
  1bhn		NUCLEOSIDE DIPHOSPHATE KINASE ISOFORM A FROM BOVINE RETINA
  1bux		3'-PHOSPHORYLATED NUCLEOTIDES BINDING TO NUCLEOSIDE DIPHOSPHATE KINASE
  1ehw		HUMAN NUCLEOSIDE DIPHOSPHATE KINASE 4
  1f3f		STRUCTURE OF THE H122G NUCLEOSIDE DIPHOSPHATE KINASE / D4T-TRIPHOSPHATE.MG COMPLEX
  1f6t		STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX
  1hhq		Role of active site resiude Lys16 in Nucleoside Diphosphate Kinase
  1hiy		Binding of nucleotides to NDP kinase
  1hlw		STRUCTURE OF THE H122A MUTANT OF THE NUCLEOSIDE DIPHOSPHATE KINASE
  1jxv		Crystal Structure of Human Nucleoside Diphosphate Kinase A
  1k44		Mycobacterium tuberculosis Nucleoside Diphosphate Kinase
  1kdn		STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE
  1leo		P100S NUCLEOSIDE DIPHOSPHATE KINASE
  1lwx		AZT DIPHOSPHATE BINDING TO NUCLEOSIDE DIPHOSPHATE KINASE
  1mn7		NDP kinase mutant (H122G;N119S;F64W) in complex with aBAZTTP
  1mn9		NDP kinase mutant (H122G) complex with RTP
  1nb2		Crystal Structure of Nucleoside Diphosphate Kinase from Bacillus Halodenitrificans
  1ncl		THERMAL STABILITY OF HEXAMERIC AND TETRAMERIC NUCLEOSIDE, DIPHOSPHATE KINASES
  1ndc		X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE COMPLEXED WITH DTDP AND MG2+ AT 2 A RESOLUTION
  1ndk		X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE
  1ndl		THE AWD NUCLEOTIDE DIPHOSPHATE KINASE FROM DROSOPHILA
  1ndp		ADENOSINE 5'-DIPHOSPHATE BINDING AND THE ACTIVE SITE OF NUCLEOSIDE DIPHOSPHATE KINASE
  1nhk		CRYSTAL STRUCTURE OF MYXOCOCCUS XANTHUS NUCLEOSIDE DIPHOSPHATE KINASE AND ITS INTERACTION WITH A NUCLEOTIDE SUBSTRATE AT 2.0 ANGSTROMS RESOLUTION
  1nlk		CRYSTAL STRUCTURE OF MYXOCOCCUS XANTHUS NUCLEOSIDE DIPHOSPHATE KINASE AND ITS INTERACTION WITH A NUCLEOTIDE SUBSTRATE AT 2.0 ANGSTROMS RESOLUTION
  1npk		REFINED X-RAY STRUCTURE OF DICTYOSTELIUM NUCLEOSIDE DIPHOSPHATE KINASE AT 1,8 ANGSTROMS RESOLUTION
  1nsk		THE CRYSTAL STRUCTURE OF A HUMAN NUCLEOSIDE DIPHOSPHATE KINASE, NM23-H2
  1nsp		MECHANISM OF PHOSPHATE TRANSFER BY NUCLEOSIDE DIPHOSPHATE KINASE: X-RAY STRUCTURES OF A PHOSPHO-HISTIDINE INTERMEDIATE OF THE ENZYMES FROM DROSOPHILA AND DICTYOSTELIUM
  1nsq		MECHANISM OF PHOSPHATE TRANSFER BY NUCLEOSIDE DIPHOSPHATE KINASE: X-RAY STRUCTURES OF A PHOSPHO-HISTIDINE INTERMEDIATE OF THE ENZYMES FROM DROSOPHILA AND DICTYOSTELIUM
  1nue		X-RAY STRUCTURE OF NM23 HUMAN NUCLEOSIDE DIPHOSPHATE KINASE B COMPLEXED WITH GDP AT 2 ANGSTROMS RESOLUTION
  1pae		nucleoside diphosphate kinase
  1pku		Crystal Structure of Nucleoside Diphosphate Kinase from Rice
  1s57		crystal structure of nucleoside diphosphate kinase 2 from Arabidopsis
  1s59		Structure of nucleoside diphosphate kinase 2 with bound dGTP from Arabidopsis
  1s5z		NDP kinase in complex with adenosine phosphonoacetic acid
  1u8w		Crystal structure of Arabidopsis thaliana nucleoside diphosphate kinase 1
  1ucn		X-ray structure of human nucleoside diphosphate kinase A complexed with ADP at 2 A resolution
  1vya		1VYA
  1w7w		Structure and mutational analysis of a plant mitochondrial nucleoside diphosphate kinase: identification of residues involved in serine phosphorylation and oligomerization.
  1wkj		Crystal Structure of Nucleoside Diphosphate Kinase from Thermus thermophilus HB8
  1wkk		Crystal Structure of Nucleoside Diphosphate Kinase from Thermus thermophilus HB8 in Complex with GDP
  1wkl		Crystal Structure of Nucleoside Diphosphate Kinase from Thermus thermophilus HB8 in Complex with ATP and ADP
  1xiq		Plasmodium falciparum Nucleoside diphosphate kinase B
  1xqi		Crystal Structure Analysis of an NDP kinase from Pyrobaculum aerophilum
  1zs6		structure of human nucleoside-diphosphate kinase 3
  2az1		Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum
  2az3		Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum in complex with CDP
  2b8p		Crystal structure of Acanthamoeba polyphaga mimivirus NDK, the first viral nucleoside diphosphate kinase
  2b8q		X-ray structure of Acanthamoeba ployphaga mimivirus nucleoside diphosphate kinase complexed with TDP
  2bef		CRYSTAL STRUCTURE OF NDP KINASE COMPLEXED WITH MG, ADP, AND BEF3
  2cwk		Crystal structure of nucleotide diphosphate kinase from Pyrococcus horikoshii
  2dxd		Crystal structure of nucleoside diphosphate kinase in complex with ATP analog
  2dxe		Crystal structure of nucleoside diphosphate kinase in complex with GDP
  2dxf		Crystal structure of nucleoside diphosphate kinase in complex with GTP analog
  2dy9		Crystal structure of nucleoside diphosphate kinase in complex with ADP
  2dya		Crystal structure of complex between Adenine nucleotide and nucleoside diphosphate kinase
  2hur		Escherichia coli nucleoside diphosphate kinase
  2hvd		Human nucleoside diphosphate kinase A complexed with ADP
  2hve		S120G mutant of human nucleoside diphosphate kinase A complexed with ADP
  2nck		CRYSTAL STRUCTURE OF MYXOCOCCUS XANTHUS NUCLEOSIDE DIPHOSPHATE KINASE AND ITS INTERACTION WITH A NUCLEOTIDE SUBSTRATE AT 2.0 ANGSTROMS RESOLUTION
  2vu5		Crystal structure of Pndk from Bacillus anthracis
  2zua		Crystal structure of nucleoside diphosphate kinase from Haloarcula quadrata
  3b54		Saccharomyces cerevisiae nucleoside diphosphate kinase
  3b6b		Crystal structure of Acanthamoeba polyphaga mimivirus nucleoside diphosphate kinase complexed with dGDP
  3bbb		Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG)
  3bbc		Crystal structure of R88A mutant of the NM23-H2 transcription factor
  3bbf		Crystal structure of the NM23-H2 transcription factor complex with GDP
  3ddi		Crystal structure of the mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with TDP
  3dkd		Crystal structure of the mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with GDP
  3ee3		Crystal structure of Acanthamoeba polyphaga mimivirus nucleoside diphosphate kinase complexed with CDP
  3eic		X-ray structure of Acanthamoeba ployphaga mimivirus nucleoside diphosphate kinase complexed with UDP
  3ejm		Crystal structure of the mimivirus NDK +Kpn mutant complexed with GDP
  3elh		X-ray structure of Acanthamoeba ployphaga mimivirus nucleoside diphosphate kinase complexed with dUDP
  3em1		Crystal structure of the mimivirus NDK +Kpn-N62L double mutant complexed with dTDP
  3emt		Crystal structure of the mimivirus NDK +Kpn-R107G double mutant complexed with dGDP
  3ena		Crystal structure of the mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with dGDP
  3etm		Crystal structure of the mimivirus NDK +KPN-N62L-R107G triple mutant complexed with CDP
  3evm		Crystal structure of the Mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with dCDP
  3evo		Crystal structure of the Mimivirus NDK +Kpn mutant complexed with dTDP
  3evw		Crystal structure of the Mimivirus NDK R107G mutant complexed with dTDP
  3fbb		Crystal structure of the Mimivirus NDK N62L-R107G double mutant complexed with UDP
  3fbc		Crystal structure of the Mimivirus NDK N62L-R107G double mutant complexed with dTDP
  3fbe		Crystal structure of the Mimivirus NDK N62L-R107G double mutant complexed with GDP
  3fbf		Crystal structure of the Mimivirus NDK N62L mutant complexed with dTDP
  3fc9		Crystal structure of the Mimivirus NDK +Kpn-N62L double mutant complexed with CDP
  3fcv		Crystal structure of the Mimivirus NDK +Kpn-N62L-R107G triple mutant complexed with dUDP
  3fcw		Crystal structure of the Mimivirus NDK N62L mutant complexed with UDP
  3fkb		Structure of NDPK H122G and tenofovir-diphosphate
  3g2x		Structure of mimivirus NDK +Kpn - N62L double mutant complexed with dTDP
  3gp9		Crystal structure of the Mimivirus NDK complexed with GDP
  3gpa		Crystal structure of the Mimivirus NDK N62L mutant complexed with CDP
  3js9		Crystal structure of nucleoside diphosphate kinase family protein from Babesia bovis
  3l7u		Crystal structure of human NM23-H1
  3mpd		Crystal structure of nucleoside diphosphate kinase from encephalitozoon cuniculi, cubic form, apo
  3ngr		Crystal structure of Leishmania nucleoside diphosphate kinase b with unordered nucleotide-binding loop.
  3ngs		Structure of Leishmania nucleoside diphosphate kinase b with ordered nucleotide-binding loop
  3ngt		Structure of Leishmania NDKb complexed with AMP.
  3ngu		Structure of Leishmania NDKb complexed with ADP.
  3pj9		Crystal structure of a Nucleoside Diphosphate Kinase from Campylobacter jejuni
  3prv		Nucleoside diphosphate kinase B from Trypanosoma cruzi
  3q83		Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase
  3q86		Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase complexed with GTP
  3q89		Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase complexed with CDP
  3q8u		Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase complexed with ADP
  3q8v		Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase complexed with UDP
  3q8y		Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase complexed with ADP and Vanadate
  3r9l		Crystal structure of nucleoside diphosphate kinase from Giardia lamblia featuring a disordered dinucleotide binding site
  3vgs		Wild-type nucleoside diphosphate kinase derived from Halomonas sp. 593
  3vgt		Wild-type nucleoside diphosphate kinase derived from Halomonas sp. 593
  3vgu		E134A mutant nucleoside diphosphate kinase derived from Halomonas sp. 593
  3vgv		E134A mutant nucleoside diphosphate kinase derived from Halomonas sp. 593
  3vvt		Crystal structure of reconstructed archaeal ancestral NDK, Arc1
  3vvu		Crystal structure of reconstructed bacterial ancestral NDK, Bac1
  3wx8		3WX8
  3zto		Orthorhombic crystal form C222 of the Aquifex aeolicus nucleoside diphosphate kinase
  3ztp		Orthorhombic crystal form P21212 of the Aquifex aeolicus nucleoside diphosphate kinase
  3ztq		Hexagonal crystal form P61 of the Aquifex aeolicus nucleoside diphosphate kinase
  3ztr		Hexagonal form P6122 of the Aquifex aeolicus nucleoside diphosphate kinase (FIRST STAGE OF RADIATION DAMAGE)
  3zts		Hexagonal form P6122 of the Aquifex aeolicus nucleoside diphosphate kinase (FINAL STAGE OF RADIATION DAMAGE)
  4anc		CRYSTAL FORM I OF THE D93N MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
  4and		CRYSTAL FORM II OF THE D93N MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
  4ane		R80N MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
  4c6a		High Resolution Structure of the Nucleoside diphosphate kinase
  4cp5		4CP5
  4di6		crystal structure of nucleoside-diphosphate kinase from Borrelia burgdorferi
  4dut		The structure of nucleoside diphosphate kinase (NDK) from Burkholderia thailandensis
  4dz6		Transition state mimic of nucleoside-diphosphate kinase from borrelia burgdorferi with bound vanadate and adp
  4ek2		The structure of nucleoside diphosphate kinase (NDK) from Burkholderia thailandensis bound to deoxyadenosine monophosphate
  4eno		Crystal structure of oxidized human nm23-H1
  4f36		Crystal structure of Nucleoside diphosphate kinase B from Trypanosoma brucei, apo form
  4f4a		Crystal structure of Nucleoside diphosphate kinase B from Trypanosoma brucei, UDP-bound form
  4fkx		Crystal structure of nucleoside diphosphate kinase B from Trypanosoma brucei bound to CDP
  4fky		Crystal structure of nucleoside diphosphate kinase B from Trypanosoma brucei bound to GTP
  4hr2		Structure of nucleoside diphosphate kinase (NDK) from Burkholderia thailandensis bound to ADP
  4kpc		4KPC
  4o0n		2.4 Angstrom Resolution Crystal Structure of Putative Nucleoside Diphosphate Kinase from Toxoplasma gondii.
  4s0m		4S0M
  4uof		4UOF
  4uog		4UOG
  4uoh		4UOH
  4w98		4W98
  4wbf		4WBF
  5bxi		5BXI
  5c7p		5C7P
  5caa		5CAA
  5cab		5CAB

• Links (links to other resources describing this domain)

• INTERPRO	IPR034907

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