NEATNEAr Transporter domain
|SMART accession number:||SM00725|
|Interpro abstract (IPR006635):|
This domain identifies a group of iron-regulated surface determinant proteins found exclusively in bacteria. Among them, the iron-regulated surface determinant protein H (isdH, also known as harA) binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. It binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone [(PUBMED:12823809)]. In Staphylococcus aureus, isdH protein contains three NEAT (NEAr Transporter) domains: IsdH(N1), IsdH(N2), and IsdH(N3). These three domains have different functions, IsdH(N1) binds hemoglobin and haptoglobin, whereas IsdH(N3) captures heme that is released from hemoglobin [(PUBMED:18984582), (PUBMED:16762363)].
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- Evolution (species in which this domain is found)
- Structure (3D structures containing this domain)
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