NEAr Transporter domain
SMART accession number:SM00725
Description: -
Interpro abstract (IPR006635):

This domain identifies a group of iron-regulated surface determinant proteins found exclusively in bacteria. Among them, the iron-regulated surface determinant protein H (isdH, also known as harA) binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. It binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone [(PUBMED:12823809)]. In Staphylococcus aureus, isdH protein contains three NEAT (NEAr Transporter) domains: IsdH(N1), IsdH(N2), and IsdH(N3). These three domains have different functions, IsdH(N1) binds hemoglobin and haptoglobin, whereas IsdH(N3) captures heme that is released from hemoglobin [(PUBMED:18984582), (PUBMED:16762363)].

Family alignment:
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There are 5397 NEAT domains in 2292 proteins in SMART's nrdb database.

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