Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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NMU Neuromedin U

SMART accession number:	SM00084
Description:	Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.
Interpro abstract (IPR008200):	Neuromedin U (NmU) [ (PUBMED:3239891) (PUBMED:1455013) ] is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated. This entry represents the sequence of the C-terminal extremity of NmU, which is extremely well conserved.
GO process:	regulation of smooth muscle contraction (GO:0006940)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 312 NMU domains in 312 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing NMU domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with NMU domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing NMU domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Domin J, Benito-Orfila MA, Nandha KA, Aitken A, Bloom SR
  • The purification and sequence analysis of an avian neuromedin U.
  • Regul Pept. 1992; 41: 1-8
  • Display abstract

  • In this study we have purified an avian homologue of neuromedin U from the chicken. Each step of the purification process was followed by a specific radioimmunoassay developed using porcine neuromedin U. Microsequence analysis characterised the peptide to be 25 amino acid residues long with the following sequence: Y-K-V-D-E-D-L-Q-G-A-G-G-I-Q-S-R-G-Y-F-F-F-R-P-R-N. Chicken neuromedin U has marked sequence similarity with the porcine peptide at its bioactive C-terminal region. Our findings demonstrate that the amino acid sequence of neuromedin U is markedly conserved in species which have diverged millions of years ago in evolutionary terms.

  • Domin J, Polak JM, Bloom SR
  • The distribution and biological effects of neuromedins B and U.
  • Ann N Y Acad Sci. 1988; 547: 391-403
• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 100.00 map04080 Neuroactive ligand-receptor interaction This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with NMU domain which could be assigned to a KEGG orthologous group, and not all proteins containing NMU domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Links (links to other resources describing this domain)

• INTERPRO	IPR008200
  PROSITE	PS00967

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