Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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NPCBM

SMART accession number:	SM00776
Description:	This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins.
Interpro abstract (IPR013222):	This entry represents a putative carbohydrate binding module (NPCBM) domain found at the N terminus of glycosyl hydrolase family 98 proteins [ (PUBMED:16212961) ]. Proteins containing this domain include CpGH98 from C. perfringens. It specifically hydrolyses fucose-containing trisaccharides from the glycotopes of blood groups A and B and is implicated for the infectivity and virulence of this pathogen [ (PUBMED:15618227) ]. CpGH98 has a central TIM barrel catalytic domain, in which putative catalytic residues may be tentatively identified, and an N-terminal novel putative carbohydrate binding module (NPCBM) [ (PUBMED:15618227) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1788 NPCBM domains in 1400 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing NPCBM domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with NPCBM domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing NPCBM domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 25.00 map00600 Sphingolipid metabolism 25.00 map00603 Glycosphingolipid biosynthesis - globoseries 25.00 map00561 Glycerolipid metabolism 25.00 map00052 Galactose metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with NPCBM domain which could be assigned to a KEGG orthologous group, and not all proteins containing NPCBM domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of NPCBM domains in PDB

  PDB code	Main view	Title
  2vmg		The structure of CBM51 from Clostridium perfringens GH95 in complex with methyl-galactose
  2vmh		The structure of CBM51 from Clostridium perfringens GH95
  2vmi		The structure of seleno-methionine labelled CBM51 from Clostridium perfringens GH95
  2vng		Family 51 carbohydrate binding module from a family 98 glycoside hydrolase produced by Clostridium perfringens in complex with blood group A-trisaccharide ligand.
  2vno		Family 51 carbohydrate binding module from a family 98 glycoside hydrolase produced by Clostridium perfringens in complex with blood group B-trisaccharide ligand.
  2vnr		Family 51 carbohydrate binding module from a family 98 glycoside hydrolase produced by Clostridium perfringens.
  2ygl		The X-ray crystal structure of tandem CBM51 modules of Sp3GH98, the family 98 glycoside hydrolase from Streptococcus pneumoniae SP3-BS71
  2ygm		The X-ray crystal structure of tandem CBM51 modules of Sp3GH98, the family 98 glycoside hydrolase from Streptococcus pneumoniae SP3-BS71, in complex with the blood group B antigen

• Links (links to other resources describing this domain)

• INTERPRO	IPR013222
  PFAM	NPCBM

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